Package: According to customer's request

Uses : a potent and specific nuclear export inhibitor

Molecular Structure:

Product description: Introduction Product Name Leptomycin B CAS No. 87081-35-4 Synonyms • Elactocin; LMB; Mantuamycin; NSC 364372; 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,10E,12E,16Z,18E-nonadecapentaenoic acid Molecular Formula C33H48O6 Molecular Weight 540.74 MDL MFCD06795848 InChI 1/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27- Appearance Liquid Property* Purity 99 % Boiling Point (760 mmHg) 725.8 °C Density 1.072 g/cm3 Flash Point 224.7 °C Refractive Index n 20/D 1.542 *The values provided are general information and not part of the product specification. Application Main Applications Leptomycin B is a potent and specific nuclear export inhibitor, and class II histone deacetylase inhibitor. In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Packaging and Handling Grade Pharma Grade Packaging According to customer's request Storage and Transportation Storage in original sealed container. Recommended storage temperature: -20 °C. Protect from moisture, heat and foreign material.