- Category :
Pharmaceuticals and Biochemicals/Biochemicals and biotech products
- CAS NO : 9014-49-7
- EC NO : 232-619-9
- Molecular Formula :
- Main Specifications : mg;g;bulk
- Synonyms : Rizolipase;Accelerase;Allzyme Lipase;Amano N-AP;Butyrinase;Chirazyme L;E.C.3.1.1.3.;Enzylon PF;Fetipase;Fluozim G 3Kh;Fungal lipase;GA 56 (Enzyme);GA-56;Glycerol ester hydrolase;Ilozyme;Lipase AP;Lipase, fungal;Lipase, triacylglycerol;Lipazin;Meito MY 30;Remzyme PL 600;Rizolipasa [INN-Spanish];Rizolipasum;Rizolipasum [INN-Latin];Steapsin;LipozymeTL100L;TheraCLEC-Lipase;Triacetinase;Triacylglycerol hydrolase;Triacylglycerol lipase;Tributyrase;Tributyrin esterase;Tributyrinase;Triglyceride hydrolase;Triglyceride lipase;Triolein hydrolase;Tween esterase;Tween hydrolase;Tweenase;UNII-8MYC33932O;UNII-FQ3DRG0N5K;Lipase of Rhizopus arrhizus var. Delemar;Plant lipase;Animal lipase;PPL;Lipozyme TL IM;Lipozyme 435;Lipozyme CALB L;Lipozyme RM IM;Palatase 20000L;Recombinant lipase A;Triacylglycerollipaza;XHlip-F;
Package: Aluminum Foil Bag
Uses : 1) Hydrolysis of trans-3-(4-methoxyphenyl) glycidic acid methyl ester [(±)-MPGM] to produce (2R,3S)-3-(4-methoxyphenyl) glycidic acid methyl ester [(-)-MPGM]. 2) Hydrolysis of (±)-naproxen methyl ester to produce (-)-naproxen. 3) Hydrolysis of fatty acid
Product description:
Recombinant Lipase A
Biocatalyst with excellent enantioselectivity
6-Recombinant Lipase A.rar
SOURCE
E.Coli
MOL.WEIGHT
65 kDa
FORM
Lyophilized powder, immobilized powder.
DESCRIPTION
Lipases (EC 3.1.1.3) are ubiquitous enzymes that catalyze the hydrolysis of fats and oils, and that play an important role in pharmaceutical. Lipases from Serratia marcescens (SML) are well-known for their excellent enantioselectivity in biocatalytic hydrolysis of trans-3-(4-methoxyphenyl) glycidic acid methyl ester [(±)-MPGM] to produce (2R, 3S)-3-(4-methoxyphenyl) glycidic acid methyl ester [(-)-MPGM], a key intermediate for the synthesis of diltiazem hydrochloride.
APPLICATION
1) Hydrolysis of trans-3-(4-methoxyphenyl) glycidic acid methyl ester [(±)-MPGM] to produce (2R,3S)-3-(4-methoxyphenyl) glycidic acid methyl ester [(-)-MPGM].
2) Hydrolysis of (±)-naproxen methyl ester to produce (-)-naproxen.
3) Hydrolysis of fatty acid esters.
4) Catalysis of ester substitution reaction.
5) Production of biodiesel.
APPLICATION NOTES
PH-stability pH 5~10
Thermal-stability Stable below 40°C, unstable at higher than 50°C.
Stability against organic solvents Higher activity In 10%-50% DMSO, isopropyl ether, petroleum ether
In 10%-25% ethanol, acetone and isopropanol
In 90% isopropyl ether, petroleum ether
50% activity In 50% acetone and isopropanol
Selectivity to different fatty-acid derivatives Priority to long-chain (> 10) fatty acid derivatives.
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