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Valsartan CAS 137862-53-4

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  Post Date: May 21,2024
  Expiry Date: May 21,2025
  Detailed Description: Cas No. :137862-53-4;137863-60-6;137862-87-4 Payment Method: LC/TT
Quick details:
Chemical Name: Valsartan
Molecular Formula: C24H29N5O3
Formula Weight: 435.5188
CAS NO.: 137862-53-4
Purity: 99%
Characteristics:white or white crystalline powder
Quality standard: USP
Packaging: 25K g/drum
Usage:it's used for various types of hypertension,and has the better protection effect on cardiovascular and renal. It can be routinely used by Hypertensive patients who are Myocardial infarction, heart failure, proteinuria, diabetes. It’s also can be combined with diuretics (such as hydrochlorothiazide)


Description:
Valsartan is an angiotensin-receptor blocker that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Valsartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system ; it competes with angiotensin II for binding to the type-1 angiotensin II receptor subtype and prevents the blood pressure increasing effects of angiotensin II.


Specification:

Test Items Standard Result
Description White or off-white powder,odorless,slightly hygroscopy

hygroscopy Qualified
Solubility Free soluble in methanol and ethanol,sparingly soluble in ethyl acetate,slightly soluble in dichloromethane, particularly insoluble in water Qualified
Identification IR,HPLC Must conform to reference standard Qualified
Absorbance at 420nm ≤0.02 ＜0.01
Water(KF) ≤2.0% 0.4%
Residue on Ignition ≤0.1% ＜0.1%
Heavy Metals ≤10ppm ＜10ppm
Related compounds
D-valsartan ≤1.0% 0.49%
Butyryl-valsartan ≤0.2% 0.02%
Benzyl-valsartan ≤0.1% N.D.
Any other individual impurity ≤0.1% 0.03%
Total impurities(Excluding D-valsartan ) ≤0.3% 0.11%
Residual Solvents
Ethanol NMT5000ppm N.D
Ethyl acetate NMT5000ppm 2283ppm
toluene NMT890ppm 89ppm
Assay(HPLC) 98.0%-102.0% 100.3%
Conclusion The results conform with USP37

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  CAS Registry Number:

137862-53-4;137863-60-6;137862-87-4
  Synonyms: ;3-methyl-2-[pentanoyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid;N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}valine;N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine;N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-D-valine;D-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;Valsartan(Diovan);n-(1-oxopentyl)-n-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-3-yl)methyl)-l-valine;
  Molecular Formula: C24H29N5O3
  Molecular Weight: 435.5188
  Molecular Structure: 137862-53-4;137863-60-6;137862-87-4 Valsartan

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