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DSIP

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  Post Date: Dec 17,2018
  Expiry Date: Dec 17,2019
  Detailed Description: Cas No. :62568-57-4 DSIP

Name:DSIP (Delta sleep-inducing peptide)
CAS: 62568-57-4
MF: C35H48N10O15
MW: 848.81
Product Categories: Peptide

1. DSIP (Delta sleep-inducing peptide) Details:

Name:DSIP (Delta sleep-inducing peptide)
Synonyms: Sleep inducing peptide;Waggdasge;Trp-ala-gly-gly-asn-ala-ser-gly-glu;Trp-ala-gly-gly-asp-ala-ser-gly-glu;Trp-ala-gly-gly-asp-ala-ser-gly-glu 4h2o;Delta sleep inducing peptide;Delta sleep-inducing peptide 4h2o;Dsip
CAS: 62568-57-4
MF: C35H48N10O15
MW: 848.81
Product Categories: Peptide
Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.

2. DSIP (Delta sleep-inducing peptide) Specification :

Purity (HPLC): 98.0%min.
Appearance: White powder
Molecular Formula: C59H83N17O17
Molecular Weight: 1302.39
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content(Karl Fischer): ≤8.0%
Acetate Content(HPIC): ≤10.0%
Specific Rotation (20/D): -55.0~-65.0°(c=1 1%HAc)
MS (ESI): Consistent
Mass Balance: 95.0~105.0%

3. DSIP (Delta sleep-inducing peptide) Description:

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced
motor activities.
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:
N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well
as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
In the brain its action may be mediated by NMDA receptors. In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats.It is unknown where DSIP is synthesized.

4. BACKGROUND AND OBJECTIVE:

Delta sleep-inducing peptide (DSIP) is an endogenous peptide that crosses the blood-brain barrier, named after its association with natural sleep and enhanced electroencephalogram (EEG) delta rhythm. The objective of this study was to determine whether DSIP could be used as an adjunct to volatile anaesthesia in humans, our hypothesis being that DSIP is a natural hypnotic that would increase anaesthetic depth. The aims were to assess depth of anaesthesia using bispectral index (BIS), the EEG and heart rate variability (HRV), and to determine whether DSIP altered the symmetry of EEG between the left and right cerebral hemispheres.
METHODS:
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) at 25, 50 or 100 nmol kg(-1). The first administration of DSIP was while awake and the second after induction of anaesthesia with propofol and maintenance with isoflurane. BIS and EEG parameters were measured continuously using a bilateral electrode montage.
RESULTS:
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia. DSIP also significantly altered bilateral symmetry of EEG.
CONCLUSION:
DSIP probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using BIS.

5. Packaging & Delivery

Packing :2mg/Vial
Package Weight :6( Grams )
Delivery Lead Time :Within 24 hours after payment
Minimum Order :10 Vials
Packing methods: Different kinds of special packing methods.
Price:The larger order is,the cheaper price is.Of course, if you want to order samples to test,ok,no problem, the moderate price will be given to you.
Sufficient stock:Sophisticated and professional logistic agent.
Well trained and disciplined packing team:Packing pictures and tacking code are provided within 12 hours after receiving the payment.
Excellent after sale service: Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.

  CAS Registry Number:

62568-57-4


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