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Linezolid
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| Post Date: | Dec 07,2018 |
| Expiry Date: | Dec 07,2019 |
| Detailed Description: |
Cas No. :165800-03-3
The main use of linezolid is the treatment of severe infections caused by Gram-positive bacteria that are resistant to other antibiotics; it should not be used against bacteria that are sensitive to drugs with a narrower spectrum of activity, such as penicillins and cephalosporins. In both the popular press and the scientific literature, linezolid has been called a "reserve antibiotic"—one that should be used sparingly so that it will remain effective as a drug of last resort against potentially intractable infections.[14][15]
In the United States, the indications for linezolid use approved by the U.S. Food and Drug Administration (FDA) are the treatment of vancomycin-resistant Enterococcus faecium infections, with or without bacterial invasion of the bloodstream; nosocomial pneumonia (hospital-acquired) and community-acquired pneumonia caused by S. aureus or S. pneumoniae; complicated skin and skin structure infections (cSSSI) caused by susceptible bacteria, including diabetic foot infection, unless complicated by osteomyelitis (infection of the bone and bone marrow); and uncomplicated skin and soft tissue infections caused by S. pyogenes or S. aureus.[3] The manufacturer advises against the use of linezolid for community-acquired pneumonia or uncomplicated skin and soft tissue infections caused by MRSA.[3] In the United Kingdom, pneumonia and cSSSIs are the only indications noted in the product labeling.[16] Linezolid appears to be as safe and effective for use in children and newborns as it is in adults.[17] |
| CAS Registry Number: | 165800-03-3 |
| Synonyms: | ;(s)-n-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide;N-({(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide;N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide;(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide; |
| Molecular Formula: | C16H20FN3O4 |
| Molecular Weight: | 337.3461 |
| Molecular Structure: | 
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| Company: | Jinan Chenghishaungda Chemical Co.,LTD [ China ] |
| Contact: | Allen |
| Tel: | 15689693073 |
| Fax: | 0531-58897032 |
| Email: | 3118607598@qq.com |
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