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|Post Date:||Jun 26,2018|
|Expiry Date:||Dec 23,2018|
Cas No. :314728-85-3
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric
modulator of AMPA receptors, and has nootropic effects in animal studies with significantly
higher potency than piracetam. A number of related compounds are known, the best known
being unifiram (DM-232)
This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.
2. Specification (Manufacturer supply directly)
Product Name Sunifiram (DM-235)
Molecular Formul C14H18N2O2
Molecular Weight 246.304
CAS No. 314728-85-3
Melting point 94.5°C-95.5°C
Appearance Off-white to white crystalline powder
1.Sunifiram activates AMPA-mediated neurotransmission.
2.Enhancing LTP in a bell-shaped dose-response relationship.
3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.
4. Packing &Storage
25kg/drum or as per customer's requirement
Store in a well-closed container away from moisture
2 years if sealed and store away from direct sun light.
Within 7 working days after order confirmation
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|CAS Registry Number:|
|Company:||Hubei Yuancheng Saichuang technology Co.1td [ China ]|
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