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Sunifiram

Inquiry
  Post Date: Jun 26,2018
  Expiry Date: Dec 23,2018
  Detailed Description: Cas No. :314728-85-3 Sunifiram
Sunifiram
1. Introduction
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric
modulator of AMPA receptors, and has nootropic effects in animal studies with significantly
higher potency than piracetam. A number of related compounds are known, the best known
being unifiram (DM-232)

This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.

2. Specification (Manufacturer supply directly)
Product Name Sunifiram (DM-235)
Synony 1-benzoyl-4-propanoylpiperazine
Molecular Formul C14H18N2O2
Molecular Weight 246.304
CAS No. 314728-85-3
Purity 99.8%
Melting point 94.5°C-95.5°C
Appearance Off-white to white crystalline powder


3. Function
1.Sunifiram activates AMPA-mediated neurotransmission.
2.Enhancing LTP in a bell-shaped dose-response relationship.
3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.
4. Packing &Storage

Packaging Detail
25kg/drum or as per customer's requirement
Storage
Store in a well-closed container away from moisture
Shelf Life
2 years if sealed and store away from direct sun light.
Delivery Detail
Within 7 working days after order confirmation

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  CAS Registry Number:

314728-85-3
  Synonyms: Sunifiram;DM-235;1-Benzoyl-4-(1-oxopropyl)piperazine
  Molecular Formula: C14H18N2O2
  Molecular Weight: 246.31176
  Molecular Structure: 314728-85-3 1-(4-Benzoylpiperazin-1-yl)propan-1-one

  Company: Hubei Yuancheng Saichuang technology Co.1td     [ China ]        
  Contact: daisy
  Tel: 86-027-50755978
  Fax:
  Email: daisy@chembj.com
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