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Colistin Sulphate

  • Post Date:

    Dec 17,2024

  • Expiry Date:

    Dec 17,2025

  • Detailed Description:

    Cas No. :1264-72-8 Quantity: 1,000Metric Tons
    Specs:EP / CP
    Payment Method: L/C,D/P,T/T

    Colistin Sulphate

     

     Colistin (Polymyxin E) is polymyxin antibiotic isolated from culture fluid of Bacillus polymyxa var colistinus bacteria in soil. Colistin is effective against most Gram-negative bacilli such as E-coil, Serpulina Hyodysenteriae, Salmonella Pullorum  and also effective on Pseudomonas aeruginosa.

     

    [Molecular Formula]    2(C52H98N16O13) · 5(H2SO4) 

     

    [Molecular Weight]      2801.27

     

    [Specifications for EP7] 

     

    Test Items

    Specifications

    Appearance

    White or almost white, hygroscopic powder

    Specific Rotation

    -63º to -73º

    Identification

    Positive

    pH

    4.0 to 6.0

    Loss on Drying

    3.5% max

    Sulphate (Dried Basis)

    16.0 to 18.0 %

    Sulphated Ash

    1.0% max

    Total Impurities

    23.0% max

    Assay HPLC (Dried Basis)

    Sum of E1,E2,E1-I,E1-7MOA,E3

    77.0% min

    Potency (Dried Basis)

    19,000 IU/mg min

     

     

    [Characteristic] 

     

      1)  Improve growth performance and conversion rate of livestock & poultry;

      2)  Inhibit Gram-negative bacteria at growth duration or dormancy state;

      3)  Prevent bacterial diarrhea & synergistic effects with other antibiotics;

      4)  No cross tolerance with broad range of antibacterial agent;

      5)  Little absorbed by intestine and stomach, no residue.

     

     [Recommended dosage]   g/ton of complete feed

     

    Target Animals

    Colistin Sulphate

    Withdrawal Period

    Swine

    <2 months

    2(60MU) – 20(600MU)

    7 Days

    2-4 months

    2(60MU) – 40(1,200MU)

    Poultry

    < 70 days

    2(60MU) – 20(600MU)

    Cattle

    < 3 months

    5(150MU) – 40(1,200MU)

    Note: 1ug of Colistin is equivalent to 30 units of Colistin; MU = Million Unit

     [Precaution] 

     

     1)   May cause damage in kidney function by overdosing;

     2)  Prohibited to use during laying period. 

     

     [Storage]   It should be kept cool and dry in well-closed original package.

     

     [Package]   25kg Drum net each

     

     [Shelf Life]   Two Years

  • CAS Registry Number:

    1264-72-8

  • Synonyms:

    ;Colistin Sulphate;n-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide sulfate (1:1);N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-5-methylheptanamide;belcomycin;

  • Molecular Formula:

    C52H98N16O13

  • Molecular Weight:

    1155.4339

  • Molecular Structure:

    1264-72-8 colistin sulfate

  • Hazard Symbols:

     T:Toxic;

  • Risk Codes:

    R25:;

  • Safety Description:

    S45:;
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