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Details for Resmetirom
| 111Category: | Intermediates/Pharmaceutical intermediates |
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| CAS NO: | 920509-32-6 | ||
| EC NO: | |||
| Molecular Formula: | C17H12Cl2N6O4 | ||
| Molecular Weight: | |||
| Specification: | 1kg/barrel, 2kg/barrel, 5kg/barrel, 10kg/barrel, 15kg/barrel, 20kg/barrel, 25kg/barrel | ||
| Packing: | Bag/Barrel | ||
| Product description: Product name: Resmetirom Resmetirom; MGL-3196; 920509-32-6; VIA-3196; 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3 ,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile; MGL 3196; Resmetirom [USAN]; MGL3196; RE0V0T1ES0 CAS No. 920509-32-6 Molecular Formula: C17H12Cl2N6O4 Molecular weight: 435.22 EINECS number: Density: 1.65±0.1g/cm3(Predicted) Storage condition: Inertatmosphere,Storeinfreezer,under-20°C Solubility: DMSO: 59.0 (maximum concentration mg/mL); 135.56 (maximum concentration mM) Form: Crystalline solid Acidity coefficient: (pKa)3.96±0.40(Predicted) Characteristics: light yellow solid powder Product Use: BioactivityResmetirom (MGL-3196,VIA-3196) is a hepatic-directed, orally active, selective thyroidhormonereceptorβ(THR-β) agonist with an EC50 of 0.21 μM and a 28-fold selectivity for THR-β over THR-α. MGL-3196 has been tested for the treatment of non-alcoholic steatohepatitis and heterozygous familial hypercholesterolemia. Product specification: 1kg/barrel, 2kg/barrel, 5kg/barrel, 10kg/barrel, 15kg/barrel, 20kg/barrel, 25kg/barrel, etc., and can be separately subcontracted according to customers' requirements. Price: Price is for reference only, call us for one-to-one quotation. MGL-3196 Upstream and downstream product information Upstream products: 4-(Propan-2-yl)pyridazine-3,6-diol 3,6-dichloro-4-isopropylpyridazine; 3,6-dichloro-4-isopropylpyridazine 6-(4-Amino-2,6-dichlorophenoxy)-4-isopropylpyridazin-3(2H)-one Advantageous products Main products: Vonorazan fumarate and intermediates, Dagliflozin and intermediates, Clevoborol and intermediates, Letemovir and intermediates, Mildronate, veterinary products (intermediates of floretanol, aflatanol and sarolanol, etc.), ropivacaine hydrochloride and intermediates, local anesthesia series (Lidocaine Hydrochloride, Lidocaine, Propamocaine Hydrochloride, Propovacaine Hydrochloride, Butocaine Hydrochloride, etc.), covering local anesthesia, local anesthesia drugs, and the intermediates. Our products cover the fields of local anesthetics, antiviral drugs, cardiovascular and cerebrovascular drugs, antitumor drugs, digestive drugs, diabetes drugs, veterinary drugs and so on. Our main advantages are high quality products, reasonable price, fast delivery and considerate after-sales service, and we support customized products. You are welcome to contact us at any time by phone, QQ, WeChat, e-mail and any other way, wholeheartedly for your service! |
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| Uses: | Pharmaceutical APIs & Intermediates | ||
| Synonyms: | MGL-3196;2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile;Resmetirom; | ||
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