Uses : Pharmaceuticals

Product description: Description Bovine pancreatic deoxyribonuclease is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding polynucleotides with free hydroxyl group at the 3' position and phosphate group at the 5' position. The optimum pH is 7.8. DNase I is activated by bivalent metals, and inhibited by chelating agents such EDTA and sodium dodecyl sulfate. DNase I can be stabilized against proteolytic digestion by 5 mM Ca2+. Deoxyribonuclease has been chromatographically purified to remove trace contaminating proteases. DNase may be used in clinic to thin and liquefy mucus in the lungs. AnalyticalTests Item Specification Methods Appearance White or pale yellow lyophilized powder Activity N.L.T. 3000 units / mg powder Solubility Soluble Loss on drying N.M.T. 0.3% USP, E.P. Residue on ignition N.M.T.1.0% USP, E.P. Storage Store in an airtight container, at a temperature of 2 ~ 8 degrees