Package: Aluminum foil and carton drum

Uses : Pharmaceuticals

Product description: Hyaluronidases play many roles in cancer metastasis. By helping to degrade the (ECM) surrounding the tumor, hyaluronidases help the cancer cell escape from the primary tumor mass and play a major role in intravasation by allowing degradation of the basement membrane of the lymph or blood vessel. Hyaluronidases again play these roles in establishment of a metastatic lesion by helping with extravation and clearing the ECM of the secondary site. Finally, hyaluronidases play a key role in the process of angiogenesis. HA fragments promote angiogenesis and hyaluronidases produce these fragments. Interestingly, hypoxia also increases production of HA and activity of hyaluronidases. As previously mentioned, there are six hyaluronidase genes in the human genome of which four can express active hyaluronidases. Each of the hyaluronidases appear to play a role in cancer progression although the roles they play and the cancers they contribute to may differ