Epothilone B
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- Category :
Pharmaceuticals and Biochemicals
- CAS NO : 152044-54-7
- EC NO :
- Molecular Formula : C27H41NO6S
- Main Specifications :
- Synonyms : Patupilone;[1S-[1R*, 3R* (E) , 7R*, 10S*, 11R*, 12R*, 16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl) ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7R,10S,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;
Package: According to customer's request
Uses : a 16-membered macrolide
Molecular Structure:
Product description:
Introduction
Product Name Epothilone B
CAS No. 152044-54-7
Synonyms Patupilone; EPO-906; EpoB; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Molecular Formula C27H41NO6S
Molecular Weight 507.68
MDL MFCD02101921
InChI 1/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
Appearance White to off-white solid
Property*
Purity 99 %
Melting Point 95-97 °C
Boiling Point (760 mmHg) 680.2 °C
Density 1.136 g/cm3
Flash Point 365.2 °C
*The values provided are general information and not part of the product specification.
Application
Main Applications Epothilone B is a 16-membered macrolide that displays microtubule stabilizing properties. Studies have shown that Epothilone B induces tubulin polymerization into microtubules in vitro. Additional experiments suggest that Epothilone B causes cell cycle arrest at the G2 stage and eventually leads to cytotoxicity.
Packaging and Handling
Grade Pharma Grade
Packaging According to customer's request
Storage and Transportation Storage in original sealed container. Recommended storage temperature: -20 °C. Protect from moisture, heat and foreign material.