Jiangsu Quality Horizons Pharmtech Co., Ltd.

Flubendazole

• Category :

  Intermediates/Pharmaceutical intermediates

• Synonyms :

  methyl N-[5-(4-fluorobenzoyl)-3H-benzoimidazol-2-yl]carbamate;methyl [6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate;[5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;

• CAS NO :

  31430-15-6

• EC NO :

  250-624-4

• Molecular Formula :

  C₁₆H₁₂FN₃O₃

• Molecular Weight :

  313.2832

• Main Specifications :

• InChI :

  InChI=1/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

• Product description :

  Substance Name	Flubendazole
  Synonyms	* Flubendazolum [INN-Latin], * (5-(4-Fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester, * Methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate, * Methyl N-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamate, * 2-Benzimidazolecarbamic acid, 5- (p-fluorobenzoyl)-, methyl ester, * AIDS-084892, * AIDS084892, * Carbamic acid, (5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl)-, methyl ester, * Carbamic acid, [5- (4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester, * CCRIS 4480, * EINECS 250-624-4, * Flubendazol [INN-Spanish], * Flubendazole [USAN:BAN:INN], * Flubenol, * Flumoxal, * Flumoxane, * Fluvermal, * N-{5-[(4-Fluorophenyl)carbonyl]benzimidazol-2-yl}methyloxymethanamide, * NSC 313680, *NSC313680, * R 17899, * R 17,889,
  Chemical Name	methyl N-[5-(4-fluorobenzoyl)-3H-benzoimidazol-2-yl]carbamate
  Molecular Formula	C16H12FN3O3
  Molecular Weight	313.283
  CAS No.	31430-15-6
  Chemical Structure
  Specification	EP/CPV
  Pharmacodynamic Properties	Flubendazole is a synthetic anthelmintic belonging to the benzimidazole carbamates which acts by inhibiting the microtubular assembly in absorptive cells of nematodes. It acts by binding to tubulin, the dimeric subunit protein of the microtubules. It inhibits microtubular assembly in absorptive cells: i.e. of intestinal cells of nematodes. This is shown by disappearance of cytoplasmic microtubules, accumulation of secretory granules in the cytoplasm due to a block in their transport, leading to an impaired coating of the cellular membrane and a decreased digestion and absorption of nutrients. Irreversible lytic degeneration of the cell, due to the accumulation of secretory substances (hydrolytic and proteolytic enzymes), results in the death of the parasite. Flubendazole is a broad-spectrum anthelminthic agent effective against endoparasites such as gastro-intestinal ascarids, hookworms, whipworms found in dogs, and active a range of gastrointestinal parasites in pigs and poultry such as roundworms, and tapeworms, Ascaris suum (large roundworm), gapeworms, Hyostrongylus rubidus (red stomach worm), Oesophagostomum dentatum (nodular worm), Trichuris suis (whip worm), Strongyloides ransomi (adult), Metastrongylus apri (lungworm).Flubendazole is ovicidal.
  Storage	Keep container tightly closed in a cool, well-ventilated area.
  MSDS	Provide as per request after the order or contract is signed.

• Molecular Structure :