Sinoway Industrial Co.LTD.

Vonoprazan Fumarate

• Category :

  Pharmaceuticals and Biochemicals

• Synonyms :

  Vonoprazan fumarate;TAK-438;TAK 438;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate;Vonaprazan;TAK438;

• CAS NO :

  1260141-27-2

• EC NO :

• Molecular Formula :

  C₂₁H₂₀FN₃O₆S

• Molecular Weight :

  461.46300

• Main Specifications :

  99% up

• Packing :

  25kg/drum

• Product description :

  Function of Vonoprazan Fumarate 1) Prevention of duodenal ulcer and gastric ulcer recurrence A randomized, double-blind, multi-center clinical phase 3 trial comparing the effects of Voronazan fumarate (10mgqd and 20mgqd) and lansoprazole (15mgqd) on nonsteroidal anti-inflammatory drug-related peptic ulcer A total of 642 patients had been diagnosed with endoscopic peptic ulcers and needed to take non-steroidal anti-inflammatory drugs. The treatment period was 24 weeks. The primary endpoint was the proportion of duodenal ulcer and gastric ulcer recurrence at 24 weeks. 2) Corrosive esophagitis (erosiveoesophagitis, EO) In a randomized, double-blind, multi-center, dose-range clinical phase 2 trial, in patients with EO, compared with lansoprazole, Voronazan fumarate showed non-inferiority and was rated in Los Angeles as C/D grade patients showed excellent effects, and oral administration of 20 mg once daily became the clinically recommended dose for the treatment of EO. A randomized, double-blind, multi-center clinical phase 3 trial comparing the efficacy of this product (20mgqd) and lansoprazole (30mgqd) on EO, a total of 409 patients participated in the study. 3) Helicobacter pylori infection (Helicobacterpylori, Hp) A randomized, double-blind, multi-center clinical phase 3 trial comparing vonolazan fumarate (20mgbid) and lansoprazole (30mgbid), combined with amoxicillin and clarithromycin, to form a triple therapy, The effect of first-line medicine to eradicate Hp was included in a total of 650 Hp-positive patients who had had gastric ulcer or duodenal ulcer. The Hp eradication rates of this product and lansoprazole in the test group were 92.6% and 75.9%, respectively. For patients with clarithromycin resistance, the Hp eradication rates in the two test groups were 82.0% and 40.0%, respectively. Significantly superior to lansoprazole. In this trial, the first 50 patients who failed first-line treatment received second-line treatment with triple therapy of this product, amoxicillin and metronidazole, and the Hp clearance rate was 98%.

• Uses :

  Corrosive esophagitis (erosiveoesophagitis, EO)

• Molecular Structure :