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Argatroban Intermediate

• Category :

  Pharmaceuticals and Biochemicals

• Synonyms :

  Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride;(2R,4R)-ethyl 1-((s)-2-amino-5-(3-nitroguanidino)pentanoyl-4-methylpiperidine-2-carboxylate;

• CAS NO :

  74874-08-1

• EC NO :

• Molecular Formula :

  C₁₅H₂₉ClN₆O₅

• Molecular Weight :

  408.88096

• Main Specifications :

• InChI :

  InChI=1/C15H28N6O5.ClH/c1-3-26-14(23)12-9-10(2)6-8-20(12)13(22)11(16)5-4-7-18-15(17)19-21(24)25;/h10-12H,3-9,16H2,1-2H3,(H3,17,18,19);1H/t10-,11?,12-;/m1./s1

• Product description :

  Argatroban is given intravenously and drug plasma concentrations reach steady state in 1-3 hours.Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared). Chemical data Formula C23H36N6O5S Mol. mass 508.635 g/mol

• Molecular Structure :