Hebei Lead Bio-Chemicals Co., Ltd.

Rifampicin

• Category :

  Pharmaceuticals and Biochemicals

• Synonyms :

  3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin;Abrifam;Dipicin;Eremfat;R/AMP;RIF;Rifa;Rifadin;Rifadin I.V.;Rifaldin;rifaldazine;Rifamate;Rifamicin AMP;Rifampin;Rifaprodin;Rifater;Rifobac;Rifoldin;Riforal;Rimactan;Rimycin;Rifamycin SV Sodium;Rifandin;(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate;

• CAS NO :

  13292-46-1

• EC NO :

  236-312-0

• Molecular Formula :

  C₄₃H₅₈N₄O₁₂

• Molecular Weight :

  822.9402

• Main Specifications :

  BP2007

• InChI :

  InChI=1/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20?/t21?,23-,24-,25-,29+,34+,35-,39+,43+/m1/s1

• Packing :

  25kgs/carton

• Product description :

  Apperance: A reddish brown to brownish red crystalline powder Bulk Density: 0.3g/ml; 0.5g/ml; 0.7g/ml; 0.8g/ml RightTBAnd other mycobacteria (including theLeprae, Etc.), in host cells inside and outside have a clear bactericidal effect. For meningococcal, Haemophilus influenzae, Staphylococcus epidermidis Streptococcus pneumoniae Legionella bacteria also have some antibacterial effect. For certain viruses, chlamydia and effective. Oral absorption of up to 90% ~ 95%, at 1 ~ 2 hours to peak plasma concentrations. This product is easy to penetrate tissues, body fluids (including cerebrospinal fluid) in. Commonly used oral dose, the effective concentration can be maintained at about 6 hours. Vd is about 1.6L/kg. Metabolism in the liver, the main metabolites still have antimicrobial activity. Since the in vivo biliary excretion of drug over about 1 / 3 of drugs from urine excretion, urine drug concentrations of up to therapeutic levels. t1 / 2 ranged from 2 to 5 hours. This product has enzymatic role, repeated after treatment, drug metabolism (including first-pass effect) to strengthen, about 2 weeks later, t1 / 2 can be shortened to 2 hours. Is mainly used inTuberculosisOtherTBCan also be used for leprosy and for erythromycin-resistantLegionella pneumonia, But also with the enzyme-resistantPenicillinOrVancomycinThe treatment of skin caused by Streptococcus or Staphylococcus aureus in osteomyelitis and endocarditis, or pneumonia for the elimination of meningococcal throat caused by Haemophilus Infectious Disease. Can also be used for anaerobic infections. Topical TreatmentTrachomaAnd the eye infections caused by susceptible ones.

• Uses :

  Pharmaceuticals

• Molecular Structure :