Zhejiang University Sunny Technology Co.,Ltd.

Colistin Sulphate

• Category :

  Pharmaceuticals and Biochemicals/Antibiotic and antimicrobial agents

• Synonyms :

  Colistin Sulphate;n-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide sulfate (1:1);N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-5-methylheptanamide;belcomycin;

• CAS NO :

  1264-72-8

• EC NO :

  215-034-3

• Molecular Formula :

  C₅₂H₉₈N₁₆O₁₃

• Molecular Weight :

  1155.4339

• Main Specifications :

  EP / CP

• InChI :

  InChI=1/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1

• Packing :

  25kg drum

• Product description :

  Colistin Sulphate

   

   Colistin (Polymyxin E) is polymyxin antibiotic isolated from culture fluid of Bacillus polymyxa var colistinus bacteria in soil. Colistin is effective against most Gram-negative bacilli such as E-coil, Serpulina Hyodysenteriae, Salmonella Pullorum  and also effective on Pseudomonas aeruginosa.

   

  [Molecular Formula]    2(C₅₂H₉₈N₁₆O₁₃) · 5(H₂SO₄) 

   

  [Molecular Weight]      2801.27

   

  [Specifications for EP7] 

   

  Test Items	Specifications
  Appearance	White or almost white, hygroscopic powder
  Specific Rotation	-63º to -73º
  Identification	Positive
  pH	4.0 to 6.0
  Loss on Drying	3.5% max
  Sulphate (Dried Basis)	16.0 to 18.0 %
  Sulphated Ash	1.0% max
  Total Impurities	23.0% max
  Assay HPLC (Dried Basis) Sum of E1,E2,E1-I,E1-7MOA,E3	77.0% min
  Potency (Dried Basis)	19,000 IU/mg min

   

   

  [Characteristic]

   

    1)  Improve growth performance and conversion rate of livestock & poultry;

    2)  Inhibit Gram-negative bacteria at growth duration or dormancy state;

    3)  Prevent bacterial diarrhea & synergistic effects with other antibiotics;

    4)  No cross tolerance with broad range of antibacterial agent;

    5)  Little absorbed by intestine and stomach, no residue.

   

   [Recommended dosage]   g/ton of complete feed

  Target Animals		Colistin Sulphate	Withdrawal Period
  Swine	<2 months	2(60MU) – 20(600MU)	7 Days
  	2-4 months	2(60MU) – 40(1,200MU)
  Poultry	< 70 days	2(60MU) – 20(600MU)
  Cattle	< 3 months	5(150MU) – 40(1,200MU)
  Note: 1ug of Colistin is equivalent to 30 units of Colistin; MU = Million Unit

   

   [Precaution] 

   1)   May cause damage in kidney function by overdosing;

   2)  Prohibited to use during laying period. 

   

   [Storage]   It should be kept cool and dry in well-closed original package.

   

   [Package]   25kg Drum net each

   

   [Shelf Life]   Two Years

• Uses :

  Antibiotic for Animal Use

• Molecular Structure :