Landz International Company Ltd.

Epothilone B

• Category :

  Pharmaceuticals and Biochemicals

• Synonyms :

  Patupilone;[1S-[1R*, 3R* (E) , 7R*, 10S*, 11R*, 12R*, 16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl) ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7R,10S,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;

• CAS NO :

  152044-54-7

• EC NO :

• Molecular Formula :

  C₂₇H₄₁NO₆S

• Molecular Weight :

  507.6825

• Main Specifications :

• InChI :

  InChI=1/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

• Packing :

  According to customer's request

• Product description :

  Introduction Product Name Epothilone B CAS No. 152044-54-7 Synonyms Patupilone; EPO-906; EpoB; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Molecular Formula C27H41NO6S Molecular Weight 507.68 MDL MFCD02101921 InChI 1/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1 Appearance White to off-white solid Property* Purity 99 % Melting Point 95-97 °C Boiling Point (760 mmHg) 680.2 °C Density 1.136 g/cm3 Flash Point 365.2 °C *The values provided are general information and not part of the product specification. Application Main Applications Epothilone B is a 16-membered macrolide that displays microtubule stabilizing properties. Studies have shown that Epothilone B induces tubulin polymerization into microtubules in vitro. Additional experiments suggest that Epothilone B causes cell cycle arrest at the G2 stage and eventually leads to cytotoxicity. Packaging and Handling Grade Pharma Grade Packaging According to customer's request Storage and Transportation Storage in original sealed container. Recommended storage temperature: -20 °C. Protect from moisture, heat and foreign material.

• Uses :

  a 16-membered macrolide

• Molecular Structure :