Hunan Huacheng Biotech,Inc.

Neohesperidin dihydrochalcone

• Category :

  Pharmaceuticals and Biochemicals

• Synonyms :

  neohesperidin dihydrochalcone from*citrus fruit;Neosperidin dihydrochalcone;3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside;

• CAS NO :

  20702-77-6

• EC NO :

  243-978-6

• Molecular Formula :

  C₂₈H₃₆O₁₅

• Molecular Weight :

  612.5764

• Main Specifications :

• InChI :

  InChI=1/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

• Product description :

  Product Name:Neohesperidin dihydrochalcone

  Botanical Name:Citrus aurantium

  Part Used: Fruit

  Application: Natural Sweetener

  Brief Info:1-99%

  .....................................................................................................................................

  Active Ingredient:Neohesperidin dihydrochalcone

  CAS No.:20702-77-6

  M.Formula： C28H36O15 　　

  M.Weight：612.58　　

  Structural formula:

  

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  Specification

  (1)1-99% Neohesperidosyl dihydrochalcone

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  Description

  Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin

  DC or simply NHDC, is an artificial sweetener derived from citrus.

  NHDC was discovered during the 1960s as part of a United States Department

  of Agriculture research program to find methods for minimizing the taste of bitter

  flavorants in citrus juices. Neohesperidin is one such bitter compound. When

  treated with potassium hydroxide or another strong base, and then catalytically

  hydrogenated, it becomes NHDC, a compound roughly 15001800 times

  sweeterthan sugar at threshold concentrations; around 340 times sweeter than

  sugar weightfor weight. Its potency is naturally affected by such factors as the

  application in which it is used, and the pH of the product.Like other highly sweet

  glycosides, such as glycyrrhizin and those found in stevia, NHDC's sweet taste

  has a slower onset than sugar's and lingers in the mouth for some time.

  Unlike aspartame, NHDC is stable to elevated temperatures and to acidic or basic

  conditions, and so can be used in applications that require a long shelf life.

  NHDC itself can stay foodsafe for up to five years when stored in optimal conditions.

  The European Union approved NHDC's use as a sweetener in 1994. It has

  not been approved as a sweetener in the United States. It is sometimes said

  that NHDC is considered a Generally Recognized as Safe flavour enhancer

  by the Flavour and Extract Manufacturers' Association, which is a trade group

  with no legal standing. NHDC has never appeared on the FDA's GRAS listing.

  It is particularly effective in masking the bitter tastes of other compounds found

  in citrus, including limonin and naringin. Industrially, it is produced by extracting

  neohesperidin from the bitter orange, and then hydrogenating this to make NHDC.

  The product is well known for having a strong synergistic effect when used in

  conjunction with other artificial sweeteners such as aspartame, saccharin,

  acesulfame potassium, and cyclamate, as well as sugar alcohols such as

  xylitol. NHDC usage boosts the effects of these sweeteners at lower concentrations

  than would otherwise be required; smaller amounts of other sweeteners are needed.

  This provides a cost benefit.

  As a flavour enhancer, NHDC is used in a wide range of products and is indicated

  by the E number E 959. It is noted particularly for enhancing sensory effects (known

  in the industry as 'mouth feel'). An example of this is 'creaminess' in dairy foods

  such as yogurt and ice cream, but is also widely favoured for use in otherwise

  naturally bitter products. Pharmaceutical companies are fond of the product as a

  means of reducing the bitterness of pharmacological drugs in tablet form, and it

  has been used for livestock feed as a means of reducing feeding time. Other

  products NHDC can be found in may include a wide variety of alcoholic beverages

  (and nonalcoholic), savoury foods, toothpaste, mouthwash and condiments such

  as ketchup and mayonnaise.

  NHDC in pure form is found as a white substance not unlike powdered sugar.

  In food it is used as a flavour enhancer in concentrations of around 45 parts

  per million (ppm) and as an artificial sweetener at around 15-20 ppm.

  Research has shown that at strengths of around and above 20 ppm,

  NHDC can produce side effects such as nausea and migraine.

  This is not widely documented, however is unquestionably known within the

  food science communities that have worked with the product, and many recommend

  wearing a surgical mask when handling pure NHDC.

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  Certificate of Analysis

  Items	Specification
  Appearance	Fine white powder(Relate to Purity)
  Odor	Characteristic
  Taste	Characteristic
  Paiticle size	Pass 80 mesh
  Loss on drying	≤5%
  Heavy metals	<10ppm
  As	<1ppm
  Assay	Result
  Neohesperidosyl dihydrochalcone	≥99%
  Total Plate Count	<1000cfu/g
  Yeast & Mold	<100cfu/g
  E.Coli	Negative
  Salmonella	Negative

• Molecular Structure :