(+)-Griseofulvin
Inquiry
| Post Date: | Sep 10,2014 |
| Expiry Date: | Mar 09,2015 |
| Detailed Description: |
Cas No. :126-07-8
Quantity: 25Kilograms Name (+)-Griseofulvin Synonyms (2S)-trans-7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2[3H],1'-[2]cyclohexene)-3,4'-dione Product Name: (+)-Griseofulvin Synonyms: (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE;(2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE;7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy;(2s-trans)-xy-6’-methyl CAS: 126-07-8 MF: C17H17ClO6 MW: 352.77 EINECS: 204-767-4 Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal;Aromatics;Chiral Reagents;VERELAN Mol File: 126-07-8.mol (+)-Griseofulvin Chemical Properties mp 218-220 °C(lit.) alpha 354 º (c=1, dimethylform) storage temp. −20°C Water Solubility practically insoluble Merck 14,4549 BRN 95226 CAS DataBase Reference 126-07-8(CAS DataBase Reference) NIST Chemistry Reference Griseofulvin(126-07-8) EPA Substance Registry System Spiro[benzofuran- 2(3H),1'-[2]cyclohexene]- 3,4'-dione, 7-chloro-2',4,6-trimethoxy- 6'-methyl-, (1'S,6'R)-(126-07-8) Safety Information Hazard Codes T,Xn Risk Statements 60-61-40-43-45 Safety Statements 53-22-36/37/39-45 WGK Germany 3 RTECS WG9800000 Hazardous Substances Data 126-07-8(Hazardous Substances Data) MSDS Information Provider Language (+)-Griseofulvin English SigmaAldrich English ACROS English ALFA English (+)-Griseofulvin Usage And Synthesis Chemical Properties Crystalline Solid Usage adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic Usage antifungal, inhibits mitosis in metaphase Usage Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy. Usage It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum General Description White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F. Air & Water Reactions Insoluble in water. Reactivity Profile (+)-Griseofulvin is incompatible with strong oxidizing agents. . Fire Hazard Flash point data for (+)-Griseofulvin are not available. (+)-Griseofulvin is probably combustible. (+)-Griseofulvin Preparation Products And Raw materials Raw materials Starch-->Oxalic acid |
| CAS Registry Number: | 126-07-8 |
| Synonyms: | ;grisovin;7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2R,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexane]-3,4'-dione;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-;(+)-Griseofulvin; |
| Molecular Formula: | C17H19ClO6 |
| Molecular Weight: | 354.7822 |
| Molecular Structure: | 
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| Hazard Symbols: |  T:Toxic; |
| Risk Codes: | R60:; R61:; R40:; R43:; |
| Safety Description: | S53:; S22:; S36/37/39:; S45:; |
| Company: | Hubei MaxSource Chem Co., Ltd. [ China ] |
| Contact: | jackie xiao |
| Tel: | +86-27-83555670 |
| Fax: | |
| Email: | maxsource14@hotmail.com |
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