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Chenodeoxycholic acid CAS 474-25-9 (jerryzhang001@chembj.com)
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| Post Date: | Apr 20,2017 |
| Expiry Date: | Apr 20,2018 |
| Detailed Description: |
Cas No. :474-25-9
Payment Method: T/T; Western Union; Moneygram and Bitcoin Chenodeoxycholic acid CAS 474-25-9 Product Name: Chenodeoxycholic acid; Synonyms: URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure; CAS: 474-25-9; MF: C24H40O4; MW: 392.57; EINECS: 207-481-8; Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor;Inhibitors; Melting point: 165-167 °C(lit.); alpha: 12 º (c=1, CHCl3); storage temp.: Refrigerator; Description: Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid, with melting point at 165-167 °C. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids produced by the liver. It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name; Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans. Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid. Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps. Like other bile acids, it can be conjugated in the liver with taurine or glycine, forming taurochenodeoxycholate or glycochenodeoxycholate. Conjugation results in a lower pKa. This means the conjugated bile acids are ionized at the usual pH in the intestine and will stay in the gastrointestinal tract until reaching the ileum where most will be reabsorbed. Bile acids form micelles which facilitate lipid digestion. After absorption, they are taken up by the liver and resecreted, so undergoing an enterohepatic circulation. Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid. Usage: A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus fa cilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. Therapeutic applications: Chenodeoxycholic acid has been used as medical therapy to dissolve gallstones. Chenodeoxycholic acid can be used in the treatment of cerebrotendineous xanthomatosis. The Australian biotechnology company Giaconda has tested a treatment for Hepatitis C infection that combines chenodeoxycholic acid with bezafibrate. As diarrhea is a complication of chenodeoxycholic acid therapy, it has also been used to treat constipation. |
| CAS Registry Number: | 474-25-9 |
| Synonyms: | ;3alpha,7alpha-Dihydroxy-5beta-cholanic acid;Chenodiol;CDCA;(3alpha,5beta,7alpha,8xi,9xi,14xi)-3,7-dihydroxycholan-24-oic acid;(5beta)-3,7-dihydroxycholan-24-oic acid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;(3alpha,5beta,7alpha,8xi,9xi,14xi)-3,7-dihydroxycholan-24-oicacid;(5beta)-3,7-dihydroxycholan-24-oicacid;Chendeoxycholicacid; |
| Molecular Formula: | C24H40O5 |
| Molecular Weight: | 408.5714 |
| Molecular Structure: | 
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| Hazard Symbols: |  Xn:Harmful; |
| Risk Codes: | R63:; |
| Safety Description: | S36/37:; S45:; |
| Company: | Nanjing Bangnuo Biotechnology Co., Ltd. [ China ] |
| Contact: | Jerry Zhang |
| Tel: | 86-25-52198306 |
| Fax: | |
| Email: | jerryzhang001@chembj.com |
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