Home > Offer to Sell > Intermediates > Pharmaceutical intermediates > Lactulose CAS 4618-18-2 for Constipation and Hepatic Encephalopathy Treatment (jerryzhang001@chembj.com)

Lactulose CAS 4618-18-2 for Constipation and Hepatic Encephalopathy Treatment (jerryzhang001@chembj.com)

Inquiry
  Post Date: Apr 20,2017
  Expiry Date: Apr 20,2018
  Detailed Description: Cas No. :4618-18-2 Payment Method: T/T; Western Union; Moneygram and Bitcoin
Lactulose CAS 4618-18-2 for Constipation and Hepatic Encephalopathy Treatment


Product Name: Lactulose;
Synonyms: MLS-50;4-0-beta-d-galactopyranosyl-d-fructose;4-o-beta-d-galactopyranosyl-d-fructos;4-o-beta-d-galattopiranosil-d-fruttofuranosio;4-O-D-Galactopyranosyl-D-fructose;bifiteral;cephulac;chronulac;

CAS: 4618-18-2;
MF: C12H22O11;
MW: 342.3;
EINECS: 225-027-7;
Product Categories: Sugars, Carbohydrates & Glucosides;Basic Sugars (Mono & Oligosaccharides);Biochemistry;Disaccharides;Sugars;Carbohydrates & Derivatives;ACILAC;Food Additives;Inhibitors;

Melting point: ~169 °C (dec.);
alpha: -47 º (C=5, H2O, 12HR);
density: 1.32g/cm;
storage temp.: Refrigerator;
Water Solubility: 76.4 G/100 ML (30 ºC);

Chemical Properties： White Powder;

Description:

Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. It is used by mouth for constipation and either by mouth or in the rectum for hepatic encephalopathy.It generally begins working after eight to twelve hours but may take up to two days to improve constipation.

Usage:

Constipation

Lactulose is used in the treatment of chronic constipation in patients of all ages as a long-term treatment. Lactulose is used for chronic idiopathic constipation, i.e. chronic constipation occurring without any identifiable cause. Lactulose may be used to counter the constipating effects of opioids, and in the symptomatic treatment of hemorrhoids as a stool softener.

The dosage of lactulose for chronic idiopathic constipation is adjusted depending on the constipation severity and desired effect, from a mild stool softener to causing diarrhea. Dosage is reduced in case of galactosemia as most preparations contain the monosaccharide galactose due to its synthesis process.

Hyperammonemia

Lactulose is useful in treating hyperammonemia (high blood ammonia), which can lead to hepatic encephalopathy. Lactulose helps trap the ammonia (NH3) in the colon and bind to it. It does this by using gut flora to acidify the colon, transforming the freely diffusible ammonia into ammonium (NH+
4) which can no longer diffuse back into the blood. It is also useful for preventing hyperammonemia caused as a side effect of administration of valproic acid.

Lactulose for hepatic encephalopathy generally requires relatively large oral dosages three or four times a day with episodic diarrhea and constant flatulence almost a certain side effect. People who take lactulose at this level of dosage generally end up wearing an adult diaper and plastic pants for any activities away from home or at night (with a chux pad for the bed) because the diarrhea can occur swiftly and without much warning.

  CAS Registry Number:

4618-18-2
  Synonyms: ;(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydro-3-furanyl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxyméthyl)tétrahydro-3-furanyl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,4,5-triol;(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxyméthyl)tétrahydrofuran-3-yl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,4,5-triol;4618-18-2;4-D-Galactopyranosyl-4-D-fructofuranose;4-O-b-D-Galactosyl-D-fructose;4-O-beta-delta-Galactopyranosyl-delta-fructose;4-O-beta-D-Galactopyranosyl-beta-D-fructofuranose;4-O-beta-D-galactopyranosyl-D-fructose;
  Molecular Formula: C12H22O11
  Molecular Weight: 342.2965
  Molecular Structure: 4618-18-2 Lactulose
  Safety Description: S24/25:;

  Company: Nanjing Bangnuo Biotechnology Co., Ltd.     [ China ]        
  Contact: Jerry Zhang
  Tel: 86-25-52198306
  Fax:
  Email: jerryzhang001@chembj.com
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.