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Nutrition Enhancer Amino Acid L-Valine CAS No. 72-18-4 (jerryzhang001@chembj.com)

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  Post Date: Mar 24,2017
  Expiry Date: Mar 24,2018
  Detailed Description: Cas No. :72-18-4 Nutrition Enhancer Amino Acid L-Valine CAS No. 72-18-4

Product Name: L-Valine;
Synonyms: (S)-(+)-VALINE;(S)-ALPHA-AMINOISOVALERIC ACID;VALINE, L-;VALINE;2-AMINO-3-METHYLBUTANOIC ACID;2-AMINOISOVALERIC ACID;H-VAL-OH;H-L-VAL-OH;

CAS: 72-18-4;
MF: C5H11NO2;
MW: 117.15;
EINECS: 200-773-6;
Product Categories: Amino Acids;Amino Acid Derivatives;Valine [Val, V];Amino Acids and Derivatives;alpha-Amino Acids;Biochemistry;Nutritional Supplements;Amino Acids;amino;

Melting point : 295-300 °C (subl.)(lit.);
alpha: 28 º (c=8, 6N HCl);
density: 1.23;
storage temp.: Store at RT.;

Water Solubility: 85 g/L (20 ºC);

HS Code: 29224995;


Chemical property: White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).

Description:

L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.

Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside.

Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.

L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.

Usage:

1. Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction.
2. L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
3. L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives.
4. Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
5. L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine.

The main effect of feed additives:

1. L- Valine added in lactating sows diets can increase milk yield. Its mechanism is that valine can affect the synthesis of alanine and release of muscle. Valine added in lactating sows diets can elevate the content of alanine in the plasma to accommodate breast tissue demand for glucose raw materials. Then milk yield can be improved. Valine is very important for the production and development of breast. And valine is limiting amino acid of lactating sows protein diets. Valine deficiency can reduce the effect of lysine. Although that adding lysine into lactation pig feed can improve the quality of dietary protein. But it can also result in the lack of valine, thereby affect sow milk yield and piglet weight gain. When the concentration of lysine is at higher level, valine will be the first limiting amino acid.
2. L-Valine can improve animals’ immune function. Valine can promote animal bone cells into mature T cells. Valine deficiency can lower levels of complement C3 and transferrin. It can hinder the growth of the thymus and peripheral lymphoid tissues, and inhibit the growth of acidic and neutral cell. When weaned lack valine, it will cause a decline in the ability of synthesis of specific antibody. If chicks lack valine, the antibody response for newcastle disease virus reduce antibody response.
3. L-Valine can affect animal endocrine levels. Studies have shown that valine that is added in lactating sows and lactating rats diets can increase the concentration of prolactin and growth hormone in plasma.


  CAS Registry Number:

72-18-4
  Synonyms: ;L-2-Amino-3-methylbutyric acid;L-Valine, FCC Grade L-2-Amino-3-methylbutyric acid, FCC Grade;H-Val-OH;2-Amino-3-methylbutanoic acid;Lvaline;L-2-Aminoisovaleric acid;(S)-(+)-2-Amino-3-methylbutyric acid;;1-2-Amino-3-methylbutyric acid;Valine;
  Molecular Formula: C5H11NO2
  Molecular Weight: 117.1478
  Molecular Structure: 72-18-4 L-Valine
  Safety Description: S24/25:Avoid contact with skin and eyes.;

  Company: Nanjing Bangnuo Biotechnology Co., Ltd.     [ China ]        
  Contact: Jerry Zhang
  Tel: 86-25-52198306
  Fax: 86-25-52198306
  Email: jerryzhang001@chembj.com
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