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Telmisartan CAS 144701-48-4 as Anti-hypertensive (jerryzhang001@chembj.com)

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  Post Date: Apr 20,2017
  Expiry Date: Apr 20,2018
  Detailed Description: Cas No. :144701-48-4 Payment Method: T/T; Western Union; Moneygram and Bitcoin
Telmisartan CAS 144701-48-4 as Anti-hypertensive


Product Name: Telmisartan;

Synonyms: TU-199;TELMISARTAN;PRITOR;MICARDIS;BIBR 277;4'[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-1H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID;4'-[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID;3-methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl sulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraene;

CAS: 144701-48-4;
MF: C33H30N4O2;
MW: 514.63;

Product Categories: Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;INTERMEDIATESOF;Antihypertensive;Imidazoles;(intermediates of telmisartan);Telmisartan;Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Other Products;Hypertension.;CARADRIN;

Melting point: 261-263°C;
density: 1.16;
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere;

Description:

Telmisartan is a novel type of blood pressure lowering drug and is a kind of specific antagonist for the angiotensin II receptor (AT I type) antagonist for the treatment of essential hypertension, replacing the angiotensin II receptor for binding with the AT I receptor subtypes (known action sites of angiotensin II) with high affinity.

Telmisartan has no site agonist effect on the AT I receptor and selectively binds with the AT I receptors with a long-lasting binding effect. It has no affinity to other receptors (including AT2 and other less characterized AT receptors). The function of other receptors remains unknown. Since telmisartan resulting in increased levels of angiotensin II, it is also possible to cause excessive stimulating effect on the receptor.

Telmisartan does not inhibit human plasma renin, nor block the ion channel. It does not inhibit the angiotensin-converting enzyme II that can alleviate the adverse reaction of the enhanced effect of bradykinin.

Administration of 80 mg of Telmisartan to the human body can almost completely inhibit the increase in blood pressure caused by angiotensin II. The inhibitory effect can last for 24 hours and is still detectable at 48 hours. Within three hours after the initial dose, the antihypertensive effect became significant gradually. At the first 4 weeks after the start of treatment, we can obtain the maximum antihypertensive effect and the efficacy can be maintained during long-term therapy.

If the treatment gets sudden interruption, the blood pressure will gradually return back to the pre-treatment level after a few days without the emergence of the rebound hypertension. In a clinical trials for direct comparison between these two kinds hypertension drugs, the incidence of dry cough in treatment group was significantly lower than that in the treatment group via angiotensin-converting enzyme inhibitor.

Usage:

It is used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart;


  CAS Registry Number:

144701-48-4
  Synonyms: ;4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid;2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propyl-benzoimidazol-1-yl]methyl]phenyl]benzoic acid;[1,1'-Biphenyl]-2-carboxylicacid,4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl];4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid;tert-butyl 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylate;
  Molecular Formula: C33H30N4O2
  Molecular Weight: 514.6268
  Molecular Structure: 144701-48-4 Telmisartan
  Safety Description: S22:;
S24/25:;

  Company: Nanjing Bangnuo Biotechnology Co., Ltd.     [ China ]        
  Contact: Jerry Zhang
  Tel: 86-25-52198306
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