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10-Deacetyl-7-xylosyl paclitaxel cas90332-63-1
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| Post Date: | Jan 11,2016 |
| Expiry Date: | Jan 10,2017 |
| Detailed Description: |
Cas No. :90332-63-1
Quantity: 1Kilograms Specs:98% Price:1 USD Metric Tons Payment Method: T/T Availability: In Stock Cat No.: 90332-63-1 Biological Description: 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. IC50 value: Target: Microtubule inhibitor 10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9. In turn, caspase-9 activated downstream caspases-3 and -6, but not caspase-8. Bid was also activated by caspase-3. Reversely, treatment with a caspase-10-specific inhibitor could not protect PC-3 cells from 7-xylosyl-10-deacetyl-paclitaxel-triggered apoptosis. Moreover, 7-xylosyl-10-deacetylpaclitaxel had no effect on the expression of CD95 and NF-kappaB proteins, indicating that apoptosis was induced through the mitochondrial-dependent pathway i... Purity: >98% Molecular formula: C50H57NO17 Molecular Weight: 943.98 Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
| CAS Registry Number: | 90332-63-1 |
| Synonyms: | 10-Deacetyltaxol 7-xyloside; b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester |
| Molecular Formula: | C50H57NO17 |
| Molecular Weight: | 943.98 |
| Molecular Structure: | 
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| Company: | SHENZHEN NEXCONN PHARMATECHS LTD. [ China ] |
| Contact: | Ms. Lin |
| Tel: | +86 755-89396905;+86 189267598 |
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| Email: | sales3@nexconn.com |
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