Home > Offer to Sell > Pharmaceuticals and Biochemicals > Respiratory system agents > 17-alpha-Methyl Testosterone
17-alpha-Methyl Testosterone
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| Post Date: | Sep 21,2016 |
| Expiry Date: | Sep 21,2017 |
| Detailed Description: |
Cas No. :58-18-4
Quantity: 1Kilograms Specs:alisa@pharm-china.com Price:1 USD Metric Tons Payment Method: Western Union, MoneyGram, Bank transfer, Bite 17-alpha-Methyl Testosterone 1. Quick Details: 17-alpha-Methyl Testosterone Alias: 17beta-hydroxy-17alpha-methylandrost-4-en-3-one; Mesterone; Andrometh; 17-Methyl Testosterone; Nu-man; Testoviron CAS No.: 58-18-4 Appearance : white crystalline powder Use: It is used as a feed additive to produce predominately male populations of tilapia. 2. We Guarantee: a. Fast Delivery: 3 work days after received payment. b. Free Resending: For long term cooperation, we guarantee all our customers will get their stuffs. c. Long Term Cooperation Discount: 5% DISCOUNT for our regular customers. 3. 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Your requirement 4. More Information About 17-alpha-Methyl Testosterone: 17-Methyltestosterone is one of the oldest available oral steroids. It is produced by many various manufacturers and sold in a number of countries including the U.S.. It is quite androgenic, with minimal anabolic effects. For athletic purposes, methyltestosterone is generally only used to stimulate aggression among power lifters and those looking to boost up their workouts. Many 17-methyltestosterone tablets are sublingual (to be placed under the tongue) for faster absorption. These tabs can generally be identified by a notable citrus flavor to them. A couple tabs placed under the tongue before a visit to the gym may make for an aggressive workout. Aside from this, methyltestosterone offers little except androgenic side effects. It is quite toxic, elevating liver enzymes and causing acne, gynecomastia, aggression and water retention quite easily. Were one to tolerate these side-effects, methyltestosterone will offer little more than some slight strength gains. 17-Methyltestosterone is a man-made form of testosterone, a naturally occurring sex hormone that is produced in a man’s testicles. Small amounts of testosterone are also produced in a woman’s ovaries and adrenal system. The combination of esterified estrogens and 17-methyltestosterone is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. This medication may also be used for purposes not listed in this medication guide. 17alpha-methyl testosterone is a synthetic androgen with affinity for the androgen receptor. 17alpha-methyl testosterone is used widely as a component of hormone replacement therapy. Previous reports have indicated that contrary to testosterone, 17alpha-methyl testosterone is not aromatized. However, 17alpha-methyl testosterone still could affect local estrogen formation by regulating aromatase expression or by inhibiting aromatase action. Both possibilities have important clinical implications. To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. We found that in both cell lines, 17alpha-methyl testosterone inhibits aromatase activity in a dose-related manner. The curve of inhibition parallels that of letrozole and gives complete inhibition at 10(-4) M 17alpha-methyl testosterone, determined by the tritium release assay. 17alpha-methyl testosterone does not have detectable effects on aromatase RNA and protein expression by Jar cells. Undifferentiated THP-1 cells had no aromatase activity and showed no effect of 17alpha-methyl testosterone, but differentiated THP-1 (macrophage-like) cells had a similar inhibition of aromatase activity by 17alpha-methyl testosterone to that seen in Jar cells. The Lineweaver-Burke plot shows 17alpha-methyl testosterone to be a competitive aromatase inhibitor. Our results show for the first time that 17alpha-methyl testosterone acts as an aromatase inhibitor. These findings are relevant for understanding the effects of 17alpha-methyl testosterone as a component of hormone replacement therapy. 17alpha-methyl testosterone may, as a functional androgen and orally active steroidal inhibitor of endogenous estrogen production, also offer special possibilities for the prevention/treatment of hormone-sensitive cancers. 5. 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Seller's Information: Company: Shanghai Yijing Pharmaceutical Co., Ltd Mob: +OO86-13O26163653 7. How to place an order: Send me an email at the address above, tell me product name and quantity. |
| CAS Registry Number: | 58-18-4 |
| Synonyms: | ;17beta-hydroxy-17alpha-methylandrost-4-en-3-one;17-hydroxy-17-methylandrost-4-en-3-one;(17beta)-17-hydroxy-17-methylandrost-4-en-3-one;Methyltestosterone;17α-Methyltestosterone;Methyl Testosterone; |
| Molecular Formula: | C20H30O2 |
| Molecular Weight: | 302.451 |
| Molecular Structure: | 
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| Hazard Symbols: |  Xn:Harmful; |
| Risk Codes: | R22:; |
| Safety Description: | S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.; |
| Company: | Shanghai Yijing Pharmaceutical Co., Ltd [ China ] |
| Contact: | Alisa |
| Tel: | +86-130-26163653 |
| Fax: | |
| Email: | alisa@pharm-china.com |
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