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3-Buten-1-ol

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  Post Date: Dec 11,2014
  Expiry Date: Jun 09,2015
  Detailed Description: Cas No. :627-27-0 Specifications 3-Buten-1-ol
The chiral piperidine (2S,4R)(VI) has been obtained as follows:
The cyclization of 3-buten-1-ol (XXII) with (S)-1-phenylethylamine (XXIII) and glyoxylic acid (XXIV) by means of tosyl chloride in THF gives a mixture of the (2S,4R) and (2R,4S) lactones (XXV), which is resolved by fractional crystallyzation of their salts with the chiral camphorsulfonic acid (XXVI), followed by elimination of the acid with ammonia to afford (2S,4R)(XXVII). The reaction of lactone (XXVII) with isopropylmagnesium chloride and tert-butylamine in THF gives (2S,4R)-N-tert-butyl-4-hydroxy-1-(1(S)-phenylethyl)piperidine-2-carboxamide (XXVIII), which is debenzylated by hydrogenation and protected with tert-butoxycarbonyl anhydride yielding (2S,4R)-N-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxamide (2S,4R)(XI), which is finally condensed with 4-(chloromethyl)pyridine (XII) as before to obtain the chiral piperidine (2S,4R)(VI), already reported.

  CAS Registry Number:

627-27-0
  Synonyms: ;3-BUTENE-1-OL;4-HYDROXY-1-BUTENE;ALLYLCARBINOL;1-HYDROXY-3-BUTENE;1-Buten-4-ol;3-buten-1-0l;3-Buten-1-O1;3-butene-1-0l;3-Butenol;3-Butenyl alcohol;BUTEN-(3)-O1-(L);CH2=CHCH2CH2OH;but-3-en-1-ol;
  Molecular Formula: C4H8O
  Molecular Weight: 72.1057
  Molecular Structure: 627-27-0 3-Buten-1-ol
  Hazard Symbols:  Xi:Irritant;
  Risk Codes: R10:;
R36/37/38:;
  Safety Description: S16:;
S26:;
S36:;

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