AZD-9291 (Mesylate)
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| Post Date: | Jun 06,2020 |
| Expiry Date: | Jun 06,2021 |
| Detailed Description: |
Cas No. :1421373-66-1
Quantity: 1Metric Tons Specs:99%min Osimertinib mesylate Basic information Product Name: Osimertinib mesylate Synonyms: Mesylate-AZD9291;Osimertinib Mesylate (Tagrisso, Mereletinib, AZD-9291);Osimertinib d6;N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate;Osimertinib methanesulfonate;Osimertinib (AZD9291) mesylate;Mereletinib mesylate, 98%, a potent and selective mutated forms EGFR inhibitor;AZD-9291 mesylate (Osimertinib mesylate CAS: 1421373-66-1 MF: C28H33N7O2.CH4O3S MW: 595.71298 EINECS: 200-064-1 Product Categories: API;AZD09 Mol File: 1421373-66-1.mol Osimertinib mesylate Structure Osimertinib mesylate Chemical Properties Safety Information HS Code 29339900 MSDS Information Osimertinib mesylate Usage And Synthesis Definition ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. Used for treatment of EGFR T790M mutation positive non-small cell lung cancer. Indications The collection of ibrutinib (Imbruvica(R), Pharmacyclics Inc.), afatinib, and osimertinib represents the small, yet expanding, group of covalent SMKIs. Ibrutinib is a non-receptor Bruton’s tyrosine kinase inhibitor approved for the treatment of relapsed chronic lymphocytic leukemia. Afatinib, approved for NSCLC in 2013 and squamous NSCLC in 2016, is a second-generation irreversible EGFR inhibitor that targets wild-type EGFR, the mutant T790M EGFR, and HER2. Osimertinib (AZD9291), which was approved by FDA in November 2015, is a third-generation irreversible EGFR inhibitor that selectively targets the mutant T790M EGFR. Rociletinib, which shares a high degree of structural similarity with that of osimertinib, is a promising covalent EGFR inhibitor developed by Clovis Oncology aimed for the treatment of patients with EGFR T790M-mutated NSCLC, until the company terminated its development in May 2016 following a negative vote fromthe FDA’sOncologic Drugs Advisory Committee. |
| CAS Registry Number: | 1421373-66-1 |
| Synonyms: | ;Osimertinib mesylate;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);Osimertinib Mesylate;AZD-9291 mesylate; |
| Molecular Formula: | C28H33N7O2.CH4O3S |
| Molecular Weight: | 595.71 |
| Molecular Structure: | 
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| Company: | shanghai missyou chemical co.,ltd. |
| Contact: | eileen zhang |
| Tel: | +86-18101936766 |
| Fax: | 021-58583907 |
| Email: | eileen@shmychem.com |
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