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Anti EstrogAnti Estrogen Muscle Building Bulking Cycle Steroids en Muscle Building Bulking Cycle Steroids

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  Post Date: Sep 26,2016
  Expiry Date: Sep 26,2017
  Detailed Description: Anti Estrogen Muscle Building Bulking Cycle Steroids

99% Purity of Exemestane / CAS No: 107868-30-4

Product details:
Product name: Exemestane
Other name: Aromasin
CAS No: 107868-30-4
Assay: 98%
Molecular Formula: C20H24O2
Molecular Weight: 296.4
Packing: 1kg/bag
Appearance: White or white crystalline powder
Usage: An antineoplastic (hormonal). Used to treat breast cancer with hormonal therapy. Aromatase inhibitors block the synthesis of estrogen
Using method: you should make exemestane into pills and 25mg/pill. you must use the exemestane pills after meal.

Function:

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body\'s estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.
Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.
The estrogen suppression rate for exemestane varies from 35% for estradiol (E2) to 70% for estrone (E1).

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