Apremilast(CC-10004)
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| Post Date: | Mar 20,2015 |
| Expiry Date: | Mar 19,2016 |
| Detailed Description: |
Cas No. :608141-41-9
Quantity: 0.5Kilograms Payment Method: T/T, Western Union Apremilast is a novel, orally available PDE4 inhibitor that inhibits spontaneous TNFα production from human rheumatoid synovial membrane cultures, ex-vivo, with similar efficacy to rolipram. In addition, apremilast effectively reduced the severity of both mAb-induced arthritis and CIA in BALB/c and DBA/1 mice, respectively, over 10 days post onset, without any evident side effects, often associated with classical PDE4 inhibitors such as rolipram. Taken together, our results show that apremilast has therapeutic potential for the treatment of RA and other chronic inflammatory conditions where TNFα plays a major pathological role. |
| CAS Registry Number: | 608141-41-9 |
| Synonyms: | ;N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide;Unii-up7qbp99pn;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;CC 10004; |
| Molecular Formula: | C22H24N2O7S |
| Molecular Weight: | 460.500214 |
| Molecular Structure: | 
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| Company: | Shanghai Sun-shineChemical Technology Co.,Ltd. [ China ] |
| Contact: | Rosie Liu |
| Tel: | +86-027-59253327 |
| Fax: | |
| Email: | sales02@sun-shinechem.com |
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