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Argatroban Intermediate

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  Post Date: Nov 13,2014
  Expiry Date: May 12,2015
  Detailed Description: Cas No. :74874-08-1 Argatroban is given intravenously and drug plasma concentrations reach steady state in 1-3 hours.Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).

Chemical data
Formula C23H36N6O5S
Mol. mass 508.635 g/mol

  CAS Registry Number:

74874-08-1
  Synonyms: ;Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride;(2R,4R)-ethyl 1-((s)-2-amino-5-(3-nitroguanidino)pentanoyl-4-methylpiperidine-2-carboxylate;
  Molecular Formula: C15H29ClN6O5
  Molecular Weight: 408.88096
  Molecular Structure: 74874-08-1 Ethyl (2R,4R)-1-[2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylate hydrochloride

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