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Betamethasone Sodium Phosphate

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  Post Date: Oct 13,2015
  Expiry Date: Apr 10,2016
  Detailed Description: Cas No. :151-73-5 Product Details
Basic Info.
Model NO.:151-73-5
Product Name:Betamethasone Sodium Phosphate /Bentelan
CAS No.:151-73-5
Appearance:White Powder
Export Markets:Global
Polciy:Re-Shipping Policy
Delivery:3-7 Working Days Door to Door
Additional Info.
Packing:1kg/Aluminum Foil Bag or as Your Requirement
Standard:SGS, ISO9001, KOSHER
Origin:China
HS Code:3001
Production Capacity:1500kg/Month
Product Description

1.  Quick Detail:
 
Betamethasone Sodium Phosphate
English Synonyms: BETMETHASONE DISODIUM PHOSPHATE;bentelan;betamethasone 21-phosphate sodium;20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-pregna-4-diene-3;21-(dihydrogenphosphate),disodiumsalt;bentelan;betamethasonedisodiumphosphate;BETMETHASONE DISODIUM PHOSPHATE;betnesol;BETAMETHASONE 21-DISODIUM PHOSPHATE;betamethasone 21-phosphate disodium
CAS NO.: 151-73-5
Assay: 98%
Molecular Formula:C22H28FNa2O8P
Molecular Weight:516.4
Specifications: CP05
Packing:1kg/tin

Usage: Hormone, has anti-inflammatory effects
Appearance: It is is a white to practically white, odorless powder, and is hygroscopic.
It is freely soluble in water and in methanol, but is practically insoluble in acetone and in chloroform.
 
2.  Description:
 

Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension, USP is a sterile aqueous suspension containing betamethasone 3 mg per milliliter as betamethasone sodium phosphate, and betamethasone acetate 3 mg per milliliter.  Inactive ingredients per mL: dibasic sodium phosphate 7.1 mg; monobasic sodium phosphate 3.4 mg; edetate disodium 0.1 mg; and benzalkonium chloride 0.2 mg as a preservative.  The pH is adjusted to between 6.8 and 7.2.
The formula for betamethasone sodium phosphate is C22H28FNa2O8P and it has a molecular weight of 516.40.  Chemically, it is 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate).
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The formula for betamethasone acetate is C24H31FO6 and it has a molecular weight of 434.50.  Chemically, it is 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate.
 
Betamethasone sodium phosphate is a white to practically white, odorless powder, and is hygroscopic.  It is freely soluble in water and in methanol, but is practically insoluble in acetone and in chloroform.
Betamethasone acetate is a white to creamy white, odorless powder that sinters and resolidifies at about 165ºC, and remelts at about 200ºC-220ºC with decomposition.  It is practically insoluble in water, but freely soluble in acetone, and is soluble in alcohol and in chloroform.

3.Application:


Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. 
Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states.  Their synthetic analogs are primarily used for their anti-inflammatory effects in disorders of many organ systems.  A derivative of prednisolone, betamethasone has a 16β-methyl group that enhances the anti-inflammatory action of the molecule and reduces the sodium- and water-retaining properties of the fluorine atom bound at carbon 9.
Betamethasone sodium phosphate, a soluble ester, provides prompt activity, while betamethasone acetate is only slightly soluble and affords sustained activity.

  CAS Registry Number:

151-73-5

  Synonyms: ;betamethasone 21-(disodium phosphate);BETA METHASONE SODIUM PHOSPHATE;20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-pregna-4-diene-3;21-(dihydrogenphosphate),disodiumsalt;bentelan;betamethasonedisodiumphosphate;BETMETHASONE DISODIUM PHOSPHATE;betnesol;BETAMETHASONE 21-DISODIUM PHOSPHATE;betamethasone 21-phosphate disodium;BETAMETHASONE 21-PHOSPHATE SODIUM SALT;BETAMETHASONE SODIUM PHOSPHATE;9a-fluoro-16b-methylprednisolone-21-(disodium phosphate);1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-;Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,DisodiumSalt,(11Beta,16Beta)-;BETAMETHASONE 21-PHOSPHATE DISODIUM SALT;Celestan;Disodium betamethasone 21-phosphate;Durabetason;NSC 90616;Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI);Vista-Methasone;disodium (11beta,16beta)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate;
  Molecular Formula: C22H28FNa2O8P
  Molecular Weight: 516.4046
  Molecular Structure: 151-73-5 betamethasone 21-phosphate sodium
  Hazard Symbols:  Xn:Harmful;
  Risk Codes: R22:;
  Safety Description: S36:;

  Company: Hubei Yuancheng Saichuang Technology Co.,Ltd.     [ China ]        
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