Canrenone
Inquiry
| Post Date: | Sep 12,2015 |
| Expiry Date: | Sep 11,2016 |
| Detailed Description: |
Cas No. :976-71-6
Quantity: 2000Kilograms Specs:ISO Price:1 USD Kilograms Payment Method: Western Union, MoneyGram, T/T Canrenone Alias: 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone CAS NO 976-71-6 Product Categories:Spironolacrone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;ASMANEX Appearance:Pale yellow to pale Green Solid Molecular weight:340.46 Molecular formula:C22H28O3 EINECS:213-554-5 Packing:Foil bag Usage:Aldosterone antagonist. Diuretic hnzz01 at ycgmp dot com Sky pe:(live:hanhan9937) Product Details: Place of Origin: China Brand Name: Yuancheng Certification: GMP,SGS,ISO,KOSHER, Model Number: 976-71-6 Payment & Shipping Terms: Minimum Order Quantity: 10g Payment Terms: Western Union, MoneyGram, T/T Description The properties of the aldosterone antagonists spironolactone and potassium canrenoate in tablet formulations were examined in two studies in healthy subjects, the first study comparing levels of their common major metabolite, canrenone, in plasma and the second study comparing the pharmacological activity of the two drugs in reversing the renal effects of the synthetic mineralocorticoid fludrocortisone. At equal dosage by weight potassium canrenoate yielded peak levels and areas under the curve for canrenone in plasma which were significantly lower than those for spironolactone, and the peak level of canrenone was reached significantly later. Comparison with published work suggests that the experimental formulation of potassium canrenoate had low bioavailability. Spironolactone produced statistically valid log dose-response curves against fludrocortisone as regards sodium excretion, potassium retention and increased urine sodium to potassium ratio. There was no significant log dose-reponse after potassium canrenoate, and a statistically valid estimate of relative potency could not be obtained. The results of the two studies seem inconsistent with the view that canrenone alone is responsible for the pharmacological activity of both drugs, and suggest that a significant part of the activity of spironolactone may be attributable to metabolites other than canrenone. Applications: Canrenone (Contaren, Luvion) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe. It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects. • We specialized in pharmaceutical chemicals' production for over 10 years, • very rich experience in custom,we have professinal packing team,and fastest delivery time, • packing pictures and tracking codes will be sent to you within 48 hours after your order. • have reshipping policy to many countries. hnzz01 at ycgmp dot com Sky pe:(live:hanhan9937) |
| CAS Registry Number: | 976-71-6 |
| Synonyms: | ;Canrenone [USAN:INN];11614 R. P.;11614 R.P;17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone;17alpha-(2-Carboxyethyl)-17beta-hydroxyandrosta-4,6-dien-3-one lactone;5-17-11-00476 (Beilstein Handbook Reference);Aldadiene;Aldadiene (VAN);BRN 0046602;Canrenona;Canrenona [INN-Spanish];Canrenonum;Canrenonum [INN-Latin];Luvion;NSC 261713;Phanurane;RP 11641;SC 9376;Spirolactone SC 14266;UNII-78O20X9J0U;17alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (8CI);Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (17alpha)-;(8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione;10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione;(10R,13S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione; |
| Molecular Formula: | C22H28O3 |
| Molecular Weight: | 340.4559 |
| Molecular Structure: | 
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| Company: | Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd [ China ] |
| Contact: | hanhan |
| Tel: | +86-181-88931013 |
| Fax: | +86-181-88931013 |
| Email: | ychzkj@yuanchengtech.com |
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