Home > Offer to Sell > Organic chemicals and Derivatives > Acid, ester and anhydride compounds > Capecitabine
Capecitabine
Inquiry
| Post Date: | Aug 14,2015 |
| Expiry Date: | Feb 10,2016 |
| Detailed Description: |
Cas No. :154361-50-9
Payment Method: L/C,T/T Pharmaceutical Intermediates---Capecitabine: Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.Capecitabine is a prodrug,that is enzymatically converted to 5-fluorouracil in the tumor,where is inhibits DNA synthesis and slows growth of tumor tissue.The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites.5'-deoxy-5-fluorocytidine(5'-DFCR)and 5'-deoxy-5-fluorouridine(5'-DFUR),to form 5-fluorouracil. Metastatic breast cancer in those resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., those who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents). Capecitabine Pharmacological effects: Action/Kinetics: An oral prodrug of 5'-deoxy-5-fluorouridine (5'DFUR) that is converted to 5-fluorouracil (5-FU). 5-FU is metabolized to 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) which cause cell injury in two ways. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase to form a covalently bound ternary complex which inhibits the formation of thymidylate from uracil. Thymidylate is essential for the synthesis of DNA so a deficiency inhibits cell division. Secondly, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate during RNA synthesis; this interferes with RNA processing and protein synthesis. Readily absorbed from the GI tract. Peak blood levels, capecitabine: 1.5 hr; peak blood levels, 5-FU: 2 hr. Food reduces the rate and extent of absorption. t1/2, capecitabine and 5-FU: 45 min. Metabolites excreted in the urine. |
| CAS Registry Number: | 154361-50-9 |
| Synonyms: | ;5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine;Pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate;Xeloda;1-(5-deoxypentofuranosyl)-5-fluoro-4-{[(pentyloxy)carbonyl]amino}pyrimidin-2(1H)-one;R-340;Ro-09-1978;N4-[(pentyloxy)carbonyl]-5'-deoxy-5-fluorocytidine; |
| Molecular Formula: | C9H12FN3O4 |
| Molecular Weight: | 245.2077 |
| Molecular Structure: | 
|
| Company: | Shandong Libaode Chemical Co., Ltd. [ China ] |
| Contact: | Mr. Mao +86-13305306284,Mr. Xu +86-13255337268 |
| Tel: | +86-530-7612366,7613088 |
| Fax: | +86-530-7613088,7612366 |
| Email: | sales@libaodechem.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
