China Epoxomicin API High purity
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| Post Date: | Oct 26,2015 |
| Expiry Date: | Apr 23,2016 |
| Detailed Description: |
Cas No. :134381-21-8
Quantity: 1000g Specs:90% Price:1 USD Kilograms Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. in vitro: Epoxomicin inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM . By inhibiting osteoblast proteasome activity, epoxomicin stimulates bone formation at concentrations as low as 10 nM. in vivo: Intraperitoneal injection of 1.5 mg/kg epoxomicin given daily for two weeks induces Parkinson’s-like symptoms in rats and addition of 100 nM epoxomicin to rat ventral midbrain cultures results in apoptosis specific to dopaminergic neurons. |
| CAS Registry Number: | 134381-21-8 |
| Synonyms: | ;BU-4061T;EPOXOMICIN, SYNTHETIC;(2R)-2-[ACETYL-(N-METHYL-L-ISOLEUCYL)-L-ISOLEUCYL-L-THREONYL-L-LEUCYL]-2-METHYLOXIRANE;n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide;N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl}-L-leucinamide;N-acetyl-N-methyl-L-isoleucyl-N-{(2S,3R)-3-hydroxy-2-[(3-methyl-1-{[(2R)-2-methyloxiran-2-yl]carbonyl}butyl)amino]butanoyl}-L-isoleucinamide; |
| Molecular Formula: | C28H50N4O7 |
| Molecular Weight: | 554.7192 |
| Molecular Structure: | 
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| Company: | BSAZ(HANGZHOU)BIOTECH CO.LTD. [ China ] |
| Contact: | Sales Manager |
| Tel: | +86-571-28257297 |
| Fax: | +86-571-56260350 |
| Email: | order@bsaz.net |
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