Home > Offer to Sell > Intermediates > Pharmaceutical intermediates > Citicoline sodium CAS 33818-15-4 for Brain Disease Treatment (jerryzhang001@chembj.com)
Citicoline sodium CAS 33818-15-4 for Brain Disease Treatment (jerryzhang001@chembj.com)
Inquiry
| Post Date: | Mar 24,2017 |
| Expiry Date: | Mar 24,2018 |
| Detailed Description: |
Cas No. :33818-15-4
Citicoline sodium CAS 33818-15-4 for Brain Disease Treatment
Product Name: Citicoline sodium Synonyms: P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM;cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt; CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT; CYTIDINE-5'-DIPHOSPHOCHOLINE, NA; CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM; CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT; CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE; CITICOLINE SODIUM SALT; CAS: 33818-15-4 ; MF: C14H25N4NaO11P2; EINECS: 251-689-1; MW: 510.31. Description: Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956.and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects. Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory. Usage: Citicoline is available as a supplement online and in stores. It is sold in over 70 countries under a variety of brand names: Cebroton, Ceraxon, Cidilin, Citifar, Cognizin, Difosfocin, Hipercol, NeurAxon, Nicholin, Sinkron, Somazina, Synapsine, Startonyl, Trausan, etc. When taken as a supplement citicoline is hydrolyzed into choline and cytidine in the intestine. Once these cross the blood-brain barrier it is reformed into citicoline by the rate-limiting enzyme in phosphatidylcholine synthesis, CTP-phosphocholine cytidylyltransferase. Memory disorders In the hippocampi of rats with induced Alzheimer's Disease, citicoline counteracts neuronal degeneration and reduces the number of apoptotic cells present. Ischemic stroke Citicoline is approved for treatment in cases of head trauma, stroke, and neurodegenerative disease in Japan and Europe. Citicoline improves the clinical outcome following an ischemic stroke as evidenced by the reduction in size of lesions caused by ischemic strokes after supplementation. It has been claimed that citicoline reduces rates of death and disability following an ischemic stroke. However, the largest trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling 2298 patients, found no benefit of administering citicoline on survival or recovery from stroke. Vision Citicoline improves visual function in patients with glaucoma and amblyopia. Application: 1. Central nervous system medication. 2. Coenzyme. For acute traumatic brain injury and brain surgery consciousness. Acute brain injury and brain surgery after a disturbance of consciousness, paralysis due to stroke can gradually restore the function of the limbs, it can also be used for functions and other central nervous system disorders of consciousness caused by acute injury, and also for ischemic cerebrovascular disease and vascular dementia. |
| CAS Registry Number: | 33818-15-4 |
| Synonyms: | ;citicoline sodium;cytidine 5'-(trihydrogen diphosphate) p'-(2-(trimethylammonio)ethyl) ester inner salt monosodium salt;sodium 5'-O-[({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphinato]cytidine; |
| Molecular Formula: | C14H25N4NaO11P2 |
| Molecular Weight: | 510.3058 |
| Molecular Structure: | 
|
| Company: | Nanjing Bangnuo Biotechnology Co., Ltd. [ China ] |
| Contact: | Jerry Zhang |
| Tel: | 86-25-52198306 |
| Fax: | 86-25-52198306 |
| Email: | jerryzhang001@chembj.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
