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Clemastine fumarate

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  Post Date: Mar 08,2021
  Expiry Date: Mar 08,2022
  Detailed Description: Cas No. :14976-57-9 Specs:White or off-white crystalline powder; 98%
Clemastine fumarate
MF: C25H30ClNO5
MW: 459.96
CAS: 14976-57-9
EINECS: 239-055-2

White or off-white crystalline powder;


Clarity and color of solution Test solution is colorless or not more intensely colored than Color matching fluid

Melting Point 140~145℃

Identification Infrared AbsorptionTLC

Specific rotation [α]D20 +15°~+18 °(c = 1 in methanol)

PH 3.2~4.2

Loss on drying ≤0.5%

Heavy Metal ≤20ppm

Individual impurity≤ 0.5%

Total Impurities ≤1.0%

Residual solvents 500ppm(Ethanol)

Assay(dried base) 98.0%~102.0%



Stability data is available.




Second generation H1 receptor antagonists

Antihistamines.


  CAS Registry Number:

14976-57-9

  Synonyms: ;clemastine hydrogen fumarate;(2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine;(2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine (2E)-but-2-enedioate;;CLEMASTINE;CLEMASTINE FUMARATE SALT;CLEMASTINUM;(2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE;(+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine;Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-;Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-;Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)- (8CI);2-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine;
  Molecular Formula: C21H26ClNO·C4H4O4
  Molecular Weight: 459.9624
  Molecular Structure: 14976-57-9 clemastine fumarate

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