Damnacanthal
Inquiry
| Post Date: | Nov 01,2016 |
| Expiry Date: | Nov 01,2017 |
| Detailed Description: |
Cas No. :477-84-9
Quantity: 500Kilograms Payment Method: TT .L/C Damnacanthal Detailed Information: Name 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde CAS NO 477-84-9 Synonym Damnacanthal Molecular Weight 282.34 M.F: C16H10O5 Purity 98%min Appearance Orange-yellow solid Place of origin China Solubility Soluble to 25 mM in DMSO Certificate SGS Documents available COA,MSDS,NMR, HPLC Packing 1Kg/bag 25Kg/Drum Shelf life 2 years Storage -20 °C, sealed, avoid light,in N2 Description: Damnacanthal is an anthraquinone which acts as a p56lck tyrosine kinase inhibitor. It can be extracted from Morinda citrifolia. have long been used in traditional medicine for the treatment of cancer . Name 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde Synonym Damnacanthal Assay ≥ 98%min CAS 477-84-9 Molecular formula: C16H10O5 Percentage Composition: C 68.09%; H 3.57%; O 28.34% Melting Point: Mp 218-218.5℃ Physical Description: Orange-yellow solid Biological Source extracted from Morinda citrifolia. primary target p56lck autophosphorylation primary target IC50 17 nM against p56lck autophosphorylation Packaging: Packaged under inert gas Storage -20 °C, sealed, avoid light,in N2 Usage A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase The period of validity 2 years Overview A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells. A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase activity. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck over PKA and PKC and >40 fold selectivity for p56lck over EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56lck over pp60src and pp59fyn. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype of ras-transformed cells. Application: It have long been used in traditional medicine for the treatment of cancer . Features : 1.Any inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. OEM/ODM Available. 5. Reasonable & competitive price, fast lead time. 6. Sample is available for your evaluation & Formulation development. 7. Faster delivery:Sample order in stock and 3-7 days for bulk production. 8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder. 9. After-Sale Service: (1) International Authorized Third-Party Test For The Products You Demand. Contact : If you have any further questions or need a sample,Please do not hesitate to contact us. ShenZhen Dieckmann Technology Development Co., LTD ShenZhen Address:2floor,3 building, Maluan Make Place,2-10south of Jinlong Road, Pingshan New district,Shenzhen Zip code: 518172 Tel: 86-755-89213952 Fax: 86-755-84813563 Email: sale@dkmchem.com |
| CAS Registry Number: | 477-84-9 |
| Company: | shenzhen Dieckmann Technology Co.,Ltd |
| Contact: | Nancy |
| Tel: | 0086-13423881513 |
| Fax: | 86-755-84813563 |
| Email: | sale@dkmchem.com |
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