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Delta sleep-inducing peptide

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  Post Date: Jan 08,2016
  Expiry Date: Jul 06,2016
  Detailed Description: Cas No. :62568-57-4 Quantity: 500Kilograms
Specs:99%
Price:1 USD Kilograms
Payment Method: T/T,Money Gram,Western Union,Bitcoin
Quick Detail:
Product Name:Delta sleep-inducing peptide(DSIP)
Specification: 1mg/vial or 2mg/vial;
CAS: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Purity: 99.0%min
Description:
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.
Its aminoacid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, it is the only neuropeptide in history whose gene is unknown, raising serious questions regarding the actual existence of this peptide in nature.
DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif: N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
In the brain its action may be mediated by NMDA receptors.In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats. It is unknown where DSIP is synthesized.
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule, but as yet no structure or gene has been found for this precursor.
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  CAS Registry Number:

62568-57-4

  Synonyms: ;EMIDELTIDE;L-tryptophyl-L-alanylglycylglycyl-L-alpha-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid;tryptophylalanylglycylglycyl-alpha-aspartylalanylserylglycylglutamic acid;Dsip;
  Molecular Formula: C35H48N10O15
  Molecular Weight: 848.8136
  Molecular Structure: 62568-57-4 trp-ala-gly-gly-asp-ala-ser-gly-glu

  Company: Guangzhou Huao Chemical Corporation Limited     [ China ]        
  Contact: crystallan
  Tel: +86-18826067841
  Fax: 39008914
  Email: crystal@ycgmp.com
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