Dexamethasone

　　Dexamethasone

　　CAS accession number: 50-02-2

　　Molecular formula: C22H29FO5

　　Molecular weight: 392.46

　　EINECS:200-003-9

　　Melting point: 255-264°C

　　The specific rotation: 75°(c=1, dioxane)

　　Water soluble: 10 mg/100 mL (25°C)

　　Technical content: 99% (HPLC)

　　Quality standard: USP/EP

　　Use: dexamethasone is mainly used for anti-inflammatory and antiallergic, suitable for rheumatoid arthritis and other collagen diseases.

　　Packing: 1,5kg/ aluminum bag

　　Dexamethasone

　　, Acidocont, Deronil, Dexacortal, dexametona, Flumeprednisolon etc.

　　Chemical name: (11β, 16α) -9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dio

　　Dexamethasone or dexamethasone, fluorine methyl prednisolone, Tokusa Mimatsu, is the sugar cortical hormone. The derivative of hydrocortisone, prednisone, its pharmacological action is mainly anti-inflammatory, anti-virus, anti-allergic, rheumatism, clinical use widely. Easily absorbed from the gastrointestinal tract, the plasma levels of T1/2 for 190 minutes, T1/2 for 3 days, intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate respectively in L and 8 hours to reach the peak plasma concentration. The plasma protein binding rate than other corticosteroids is low. The anti-inflammatory activity of 0.75mg is equivalent to 5mg prednisolone.

　　Dexamethasone and other glucocorticoids, anti-inflammatory, anti - endotoxin, suppress immunity, resistance to shock and enhance the stress response and other pharmacological effects, it is widely used in all the treatment of many diseases, such as autoimmune diseases, inflammation, allergy, asthma and Department of Dermatology, the Department of Ophthalmology disease. Dexamethasone sodium phosphate injection is to rescue the dying patients indispensable first-aid medicines, in recent years, due to drug medicine clinicians use of dexamethasone sodium phosphate in the treatment and prevention of various types of allergies and treating viral cold have a fever and other symptoms, the clinical dosage of dexamethasone has increased year by year, China has become the world's largest dexamethasone market.

　　Dexamethasone anti-inflammation, anti-allergic and antitoxic effects than prednisone more sodium and water retention, less side effect, intramuscular or intravenous drip can.

50-02-2