EX-527(Selisistat)
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| Post Date: | Apr 03,2015 |
| Expiry Date: | Apr 02,2016 |
| Detailed Description: |
Cas No. :49843-98-3
Quantity: 50g Specs:98% purity Payment Method: T/T, Western Union EX-527 is a novel, potent, and specific small-molecule inhibitor of SIRT1 catalytic activity to examine the role of SIRT1 in p53 acetylation and cell survival after DNA damage. Treatment with EX-527 dramatically increased acetylation at lysine 382 of p53 after different types of DNA damage in primary human mammary epithelial cells and several cell lines. Significantly, inhibition of SIRT1 catalytic activity by EX-527 had no effect on cell growth, viability, or p53-controlled gene expression in cells treated with etoposide. EX-527 acted synergistically to increase acetyl-p53 levels, confirming that p53 acetylation is regulated by SIRT1. |
| CAS Registry Number: | 49843-98-3 |
| Company: | Shanghai Sun-shineChemical Technology Co.,Ltd. [ China ] |
| Contact: | Rosie |
| Tel: | +86-027-59253327 |
| Fax: | 0086-27-5925 3326 |
| Email: | sales02@sun-shinechem.com |
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