Home > Offer to Sell > Pharmaceuticals and Biochemicals > Hormones and synthetic substitutes > Factory pull Mifepristone Hot Sell
Factory pull Mifepristone Hot Sell
Inquiry
| Post Date: | Jun 29,2018 |
| Expiry Date: | Dec 26,2018 |
| Detailed Description: |
Cas No. :84371-65-3
Quantity: 1Metric Tons Price:1 USD Kilograms Payment Method: Wertern Union, Money Gram, T/T , Bitcoin Basic Info: Name:Mifepristone Apearance: CAS:84371-65-3 MF:C29H35NO2 MW:429.59 Shipment:EMS,DHL,TNT,UPS,Fedx Package:disguised Payment: Bank Transfer,Bitcoin,WU,MoneyGram Chemical properties Melting point 150℃. [α] D20 + 138.5 (c = 0.5, chloroform). Acute toxicity LD50 mice (g/kg):> 2.6 intraperitoneal injection. Use of new anti-progesterone, and anti-glucocorticoid activity, without progesterone, estrogen, androgen and anti-estrogenic activity. And progesterone receptor affinity 5 times stronger than progesterone. For anti-early pregnancy, urinary arrest by pregnancy, fetal death, such as induced labor. Purposes: anti-early pregnancy drug Production process Method 1: Starting from the 3-position ketal compound (I) of 4,9-estrodien-3,17-dione, reacting with propyne magnesium bromide Grignard reagent, introducing propynyl To give the compound (II). Followed by selective epoxidation of the 5-position olefinic bond to give the compound (III). Then, p-dimethylaminophenyl group was introduced into p-dimethylaminobenzene bromide in tetrahydrofuran containing cupric bromide-methyl sulfide complex to give compound (IV). Finally, in methanol, hydrochloric acid hydrolysis and dehydration, mifepristone. Yield 21.5%. Method 2: 4,9-estrodien-3,17-dione as the raw material, the 3-carbonyl protection; and then epoxidation, and then in the 17-introduction of propynyl, in the 11-bit introduction of the Dimethylaminophenyl, and finally hydrolyzed to obtain mifepristone. In contrast to Scheme 1, the reaction steps are the same only in the order of epoxidation and introduction of propynyl. The overall yield of 35% -40%. Welcome inquiry and trying, here is Amy serving.If more details,emails pls. |
| CAS Registry Number: | 84371-65-3 |
| Synonyms: | ;Mifepriston Dianhydride;(11R,13S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; |
| Molecular Formula: | C29H35NO2 |
| Molecular Weight: | 429.5937 |
| Molecular Structure: | 
|
| Company: | Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd [ China ] |
| Contact: | Yu Chengzhen |
| Tel: | 86-731-22290202 |
| Fax: | |
| Email: | hnzz01@ycgmp.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
