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Fludarabine phosphate
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| Post Date: | Jun 06,2020 |
| Expiry Date: | Jun 06,2021 |
| Detailed Description: |
Cas No. :75607-67-9
Quantity: 1Metric Tons Specs:99%min Product Name: Fludarabine phosphate Synonyms: ((2R,3S,4S,5R)-5-(6-AMINO-2-FLUORO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE;FLUDARABINE PHOSPHATE (FLUDARABINE 5''-MONOPHOSPHATE);2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine;9-(5-O-Phosphono-β-D-arabinofuranosyl)-2-fluoro-9H-purine-6-amine;F-ara-AMP;9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate;Fludarabine Phosphate (300 mg);Fludarabine Phosphate(Fludara) CAS: 75607-67-9 MF: C10H13FN5O7P MW: 365.2116842 EINECS: 616-242-0 Product Categories: Anti-cancer&immunity;Inhibitors;Active Pharmaceutical Ingredients;Antineoplastics;Antineoplastic;API Mol File: 75607-67-9.mol Fludarabine phosphate Chemical Properties Melting point 203°C(dec.)(lit.) alpha [α]D20 +10～+14゜(c=0.5,H2O) Boiling point 864.2±75.0 °C(Predicted) density 2.39±0.1 g/cm3(Predicted) RTECS UO7440900 storage temp. -20°C solubility DMSO: soluble1mg/mL form Powder pka 1.86±0.10(Predicted) color white Water Solubility Soluble in DMSO or water at 5mg/ml Merck 14,4126 InChIKey GIUYCYHIANZCFB-GFRUICAKSA-N CAS DataBase Reference 75607-67-9(CAS DataBase Reference) Safety Information WGK Germany 3 HS Code 2934990002 MSDS Information Fludarabine phosphate Usage And Synthesis Description Fludarabine phosphate is an antimetabolite indicated for the treatment of B cell lymphocytic leukemia. It is reportedly effective in patients refractory to other therapies. Fludarabine phosphate acts by inhibiting primer RNA synthesis. Its side effects include bone marrow suppression, anemia, thrombocytopenia and neutropenia. Chemical Properties White or almost white, crystalline powder, hygroscopic. Originator Southern Research Institute (U.S.A.) Uses anticonvulsant Definition ChEBI: A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Onc incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. Brand name Fludara (Berlex). |
| CAS Registry Number: | 75607-67-9 |
| Synonyms: | ;Fludarabin Phosphate;9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate;9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogen phosphate);2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine;2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine;9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate;2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine;9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate; |
| Molecular Formula: | C10H13FN5O7P |
| Molecular Weight: | 365.2117 |
| Molecular Structure: | 
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| Company: | shanghai missyou chemical co.,ltd. |
| Contact: | eileen zhang |
| Tel: | +86-18101936766 |
| Fax: | 021-58583907 |
| Email: | eileen@shmychem.com |
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