Formestane
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| Post Date: | Sep 21,2016 |
| Expiry Date: | Sep 21,2017 |
| Detailed Description: |
Cas No. :566-48-3
Quantity: 1Kilograms Specs:alisa@pharm-china.com Price:1 USD Kilograms Payment Method: Western Union, MoneyGram, Bank transfer, Bite Formestane 1. Quick Details: Synonyms: 4-hydroxy-androst-4-ene-17-dione;4-hydroxy-delta(sub4)-androstenedione;4-HYDROXYANDROST-4-ENE-3,17-DIONE;4-HYDROXYANDROSTENEDIONE;4-HYDROXY-4-ANDROSTENE-3,17-DIONE;4-ANDROSTEN-4-OL-3,17-DIONE;4-OHA;CGP-32349 CAS: 566-48-3 MF: C19H26O3 MW: 302.41 2. We Guarantee: a. Fast Delivery: 3 work days after received payment. b. Free Resending: For long term cooperation, we guarantee all our customers will get their stuffs. c. Long Term Cooperation Discount: 5% DISCOUNT for our regular customers. 3. 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Your requirement 4. More Information About Formestane: Formestane is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme. Formestane was originally used as an injectable for breast cancer patients, but due to its possible androgenic effects it has largely been replaced by non-steroidial AIs in the medical community. Most of its use is now is limited to the bodybuilding community since it is available as a legal dietary supplement for reducing estrogen and increasing testosterone production. Although formestane can effectively reduce estrogen through oral consumption, its low oral bioavailability has lead to the development of several transdermal based products (which appear to offer higher efficacy at a lower dose). Relative to 6-oxo and ATD, Formestane is a more potent aromatase inhibitor, which appears to effectively reduce natural estrogen levels by as much as 50% within several days (while higher doses may further suppress estrogen). Because of formestanes potent ability at reducing estrogen it will tend to reduce HDL levels, while increasing LDL levels, thus harming the cholesterol profile. For this reason, it is recommended to limit cycles of formestane to 8 weeks max. Because formestane also has a strong affinity for the 5a-reductase enzyme it will reduce DHT levels in the body by effectively competing with testosterone for the 5a-reductase. Formestane converts to the active androgen 4-hydroxytestosterone which has about half the anabolic potency, and about 25% of the androgenic potency as testosterone. This would suggest that fairly high doses of formestane (800-1000mg/day) could lead to some level of anabolic enhancement (although the amount required for this would surely lead to undesirably low estrogen levels). Formestane is successfully used as a standalone during re-composition cycles to help reduce “bloat” and fat storage. It can also be used as an anti-estrogen to counter aromatization of aromatizing steroids. Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and 30% during treatment with intramuscular formestone 250 or 500mg once every 2 weeks, and a further 20 to 30% of patients experience disease stabilisation. The median duration of response is between 8 and 14 months. Highest response rates are observed in soft tissue metastases, in patients with estrogen-responsive tumours and in those showing a response to previous endocrine therapy. Furthermore, there is some evidence to suggest that higher response rates are achieved with formestane 500 versus 250mg once every 2 weeks. In comparative studies, the clinical efficacy of intramuscular formestane 250mg did not differ significantly from that of oral megestrol when administered as second-line endocrine therapy to patients with advanced disease in whom previous tamoxifen therapy had failed. In addition, formestane produced a response rate, duration of response and overall survival rate that was not significantly different from that of oral tamoxifen when administered as first-line endocrine therapy to patients with advanced disease, but tamoxifen was superior in some measures. Further investigation of these 2 agents, including the higher dosage of formestane (500mg), is necessary to confirm their relative efficacies. Formestane is well tolerated by the majority of patients; adverse events rarely necessitate cessation of therapy. The most common adverse events are local reactions at the injection site and systemic events usually related to the effect of the drug on the hormonal milieu. The systemic tolerability of formestane is similar to that of tamoxifen but better than that of megestrol. Thus, formestane is effective and well tolerated as first-line endocrine therapy for advanced disease. However, at present, it is unlikely to challenge tamoxifen in this indication, based on recent findings from a large comparative study and the fact that formestane requires intramuscular administration. Nonetheless, formestane, which appears to have a better tolerability profile than other currently available second-line agents (including megestrol and the aromatase inhibitor aminoglutethimide), is a valuable drug for the second-line treatment of postmenopausal women with advanced breast cancer. 5. Key words: Buy Formestane, Formestane raw powder, Formestane anabolic steroid powder, Formestane price, anabolic steroid powder Formestane, Formestane COA, Formestane manufacturer, Formestane powder, body building steroid Formestane, body building supplement Formestane, Formestane for muscle gaining, Formestane for fat burning, Formestane injection, Formestane semi-finished injection, Formestane steroid raw, Formestane raw material, Formestane fine powder, high purity Formestane powder, Formestane 99% assay, Formestane CAS, Formestane HPCL, Formestane factory 6. Seller's Information: Company: Shanghai Yijing Pharmaceutical Co., Ltd Mob: +OO86-13O26163653 7. How to place an order: Send me an email at the address above, tell me product name and quantity. |
| CAS Registry Number: | 566-48-3 |
| Synonyms: | ;Formestane;B, Aromatase inhibitor;4-hydroxyandrost-4-ene-3,17-dione;(8xi,9xi,14xi)-4-methylandrost-4-ene-3,17-dione;4-Hydroxyandrostenedione;4-Hydroxy-4-androstenedione; |
| Molecular Formula: | C20H28O2 |
| Molecular Weight: | 300.4351 |
| Molecular Structure: | 
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| Hazard Symbols: |  T:Toxic; |
| Risk Codes: | R60:; |
| Safety Description: | S53:; S36/37/39:; S45:; |
| Company: | Shanghai Yijing Pharmaceutical Co., Ltd [ China ] |
| Contact: | Alisa |
| Tel: | +86-130-26163653 |
| Fax: | |
| Email: | alisa@pharm-china.com |
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