GW501516
Inquiry
| Post Date: | Sep 25,2018 |
| Expiry Date: | Mar 24,2019 |
| Detailed Description: |
Cas No. :317318-70-0
Quantity: 0.02Kilograms Specs:powder Price:00 USD Metric Tons Payment Method: T/T Name: GW501516 CAS No.: 317318-70-0 Appearance: white powder Purity : ≥ 99% Molecular formula: C21H18F3NO3S2 Molecular weight: 453.50 Detail: GW501516 also known as GW-501,516, GW1516 and GSK-516.It is a selective agonist (activator) of the PPARδ receptor. It was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases. GW501516 is a synthetic ligand of PPARδ and belongs to the phenoxyacetic acid derivative. After binding to GW501516, activated PPARδ forms a heterodimer with 9-cis retinoid receptor (RXR) And then identify the peroxisome proliferator response element (PPRE) upstream of the target gene promoter to regulate gene transcription, translation and biological effects downstream of the target gene. GW501516 inhibits apoptosis of ox-LDL or high glucose-induced HUVECs and attenuates the inhibitory effect of ox-LDL or high glucose on HU-VECs activity. |
| CAS Registry Number: | 317318-70-0 |
| Synonyms: | ;GW 501516;GW501516;Acetic acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-;{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid;GW-501516; |
| Molecular Formula: | C21H18F3NO3S2 |
| Molecular Weight: | 453.4977 |
| Molecular Structure: | 
|
| Company: | Wuhan Fantaike pharmaceutical Technology Co., Ltd [ China ] |
| Contact: | Sara |
| Tel: | 02787742566 |
| Fax: | |
| Email: | sara@fantike.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
