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Genz-123346

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  Post Date: Apr 03,2015
  Expiry Date: Apr 02,2016
  Detailed Description: Cas No. :491833-30-8 Quantity: 50g
Specs:98% purity
Payment Method: T/T, Western Union
Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer
activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.

  CAS Registry Number:

491833-30-8


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