| Detailed Description: |
RecombinantHuman CXCL12 is a non-glycosylated polypeptide chain containing 68 aminoacids and having a molecular weight of 8,004 Da, was expressed in E.coli. Thesequence of the first five N-terminal amino acids was determined to beLys-Pro-Val-Ser-Leu.；This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]SDF-1(stromal cell-derived factor-1) is small cytokine belonging to the chemokinefamily that is officially designated Chemokine (C-X-C motif) ligand 12(CXCL12). Stromal cell-derived factors 1-alpha and 1-beta are small cytokinesthat belong to the intercrine family, members of which activate leukocytesand are often induced by proinflammatory stimuli such as lipopolysaccharide,TNF, or IL1. The intercrines are characterized by the presence of 4 conservedcysteines that form 2 disulfide bonds. They can be classified into 2subfamilies. In the CC subfamily, which includes beta chemokine, the cysteineresidues are adjacent to each other. In the CXC subfamily, which includesalpha chemokine, they are separated by an intervening amino acid. The SDF1proteins belong to the latter group. http://www.creative-diagnostics.com/Recombinant-Human-Chemokine-C-X-C-motif-Ligand-12-a-a-68-Polypeptide-4214-427.htm
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