| Detailed Description: |
RecombinantHuman FLT3LG is asingle, non-glycosylated, polypeptide chain containing 155 amino acids andhaving a molecular mass of 17,605Da, the sequence of the first fiveN-terminal amino acids was determined and was found to beThr-Gln-Asp-Cys-Ser. Contains；Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]Fms-related tyrosine kinase 3 ligand (FLT3LG) isa protein which in humans is encoded by the FLT3LG gene. Flt3 ligand (FL) isa hematopoietic four helical bundle cytokine. It is structurally homologousto stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergywith other growth factors, Flt3 ligand stimulates the proliferation anddifferentiation of various blood cell progenitors. http://www.creative-diagnostics.com/Recombinant-Human-Fms-related-Tyrosine-Kinase-3-Ligand-a-a-155-Polypeptide-4211-427.htm
|
