| Detailed Description: |
RecombinantHuman NT-3 is a single non-glycosylated polypeptide chain containing 119amino acids and having a molecular weight of 13,606.29 Da, was expressed inE. coli. The sequence of the first five N-terminal amino acids was determinedto be Tyr-Ala-Glu-Hi；The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]Neurotrophin-3is a protein that in humans is encoded by the NTF3 gene. The protein encodedby this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor)family of neurotrophins. It is a protein growth factor which has activity oncertain neurons of the peripheral and central nervous system; it helps tosupport the survival and differentiation of existing neurons, and encouragesthe growth and differentiation of new neurons and synapses. NT-3 was thethird neurotrophic factor to be characterized, after nerve growth factor(NGF) and BDNF (Brain Derived Neurotrophic Factor). http://www.creative-diagnostics.com/Recombinant-Human-Neurotrophin-3-Polypeptide-a-a-119-4260-427.htm
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