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Hydroxypropyl methyl Cellullose (HPMC)

Inquiry
  Post Date: Apr 29,2014
  Expiry Date: Oct 26,2014
  Detailed Description: Techinical specifications of
Pharmaceutical Grade
(conforming to Q/09FRT001-2000
and standard of USP30)
Index Type
Items HPMC
65RT 60RT 75RT
Hydroxypropoxyl
content:wt% 4.0-7.5 7.0-12.0 4.0-
12.0
Methoxyl content:wt% 27.0-30.0
28.0-30.0 19.0-24.0
Gelation temperature℃ 62-68 58-64
70-90
Ash content:wt% Not more than 1.0
Moisture:wt% Not more than5.0
Viscosity:(2%by
weight at 20℃) 5-100000
PHvalue(1%by
weight at 25℃) 4-8
Chloriides:(NACL)
wt% Not more than 0.2
Arsenic:ppm Not more than 2
Heavy metals:ppm Not more than 20



Main Specification of Industral
Grade
Index Type
Items 60RT 65RT 75RT
Methoxyl content:wt% 28-30% 27-
30% 19-24%
Hydroxypropoxyl content:wt% 7-12%
4-7.5% 4-12%
Gelation temperature℃ 58-64 62-68
70-90
Loss on drying: wt% ≤5%
Ash content:wt% ≤3%
PHvalue(1%by weight at 25℃) 4-8
Viscosity:(2%by
weight at 20℃) 5-100000




Physical and chemical properties
Particle size: usp 24:98.5%
passes through 100 mesh sieve;
100% passes though 80 mesh sieve.
Tech Grade: 99% passes
through 40 mesh sieve
Charring temperatrue:280-300℃,
Bulkdensity of the powder:0.25-
0.70g/cm3 (Usually around
0.5g/cm) 3
Ture specific gravity:1.26-1.31
Broming temperature:190-
200℃,Surface tension:2% water
solution surface tension 42-
56dyn/cm.

Solubility: Dissolved in water
and some organic solvent such as
ethanol, propyl alcohol, ethylene
chloride.The water solution is of
surface grades. For example,
among 60RT HPMC, 60 is gelation
temperature. Namely, 2%water
solution will form gelation at
60℃.That is the gelation property
of HPMC. And the solubility
degree some differences exist
among different HPMC.HPMC has
stability in water and thickening
ability salt resistance, surface
activity, thermal gelation, ash
content, PH-stability water
retention shape retention shape
retention shape retention,
lubricity and film forming.

Main uses of HPMC
The product is a medicinal
accessory material of many uses.
It can be used for densifiers,
dispersing agent, emulsifying
agent, lubricator and film former
etc. It’s used as an adhesive and
coating film in tablets,
Increasing markedly rate of
dissolution and release, and
trengthing the water-proofing for
tablets and also be used as mixed
dispersing agent, eye-drop agent,
controlled released matrix
tablets. It is combined with
other synthetic polymers and gel-
type drug products to prevent the
separation If water and alcohol
in aqueous transparent jelly
drugs and to improve water
retention. Other uses, it can be
used in food or in cosmetics, and
daily chemical industries(main
used in Paint, Printing and
coating, PVC industry,etc) too.
Process for dissolving HPMC
1. Place the required
amount of hot water heated to
above 85℃ in a vessel and HPMC
gradually added while stirring
gently, at first HPMC floats on
the Surface of the water, but it
is gradually dispersed to form a
uniform slurry, cool the slurry
while stirring it.
2. Place one-thirds of the
required amount of water, heat to
above 85℃ in a vessel, disperse
HPMC and prepare a hot slurry
while stirring, cool the
resultant mixture.

Package. Storage. Transportation
USP24: packed in fiber drum and
lining with polyethylene film
bag.Net weight 25kg per drum.
Tech.Grade: 25Kgs bags
Direct sunshine and raining,
moisture must be avoided.





  Company: JOYLONG CHEMICALS CO.,LTD     [ China ]          
  Contact: Tina
  Tel: 86-731-85360795
  Fax: 86-731-85360699
  Email: joylong@jlcchem.com
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