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Live Cell Growth Factor

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  Post Date: Sep 21,2016
  Expiry Date: Sep 21,2017
  Detailed Description: Cas No. :00-00-0 Quantity: 1Kilograms
Specs:alisa@pharm-china.com
Price:1 USD Kilograms
Payment Method: Western Union, MoneyGram, Bank transfer, Bite
Live Cell Growth Factor

1. Quick Details:
Growth factors, defined as polypeptides that stimulate cell proliferation, are major growth-regulatory molecules for cells in culture and probably also for cells in vivo. Nontransformed cells show an absolute requirement for growth factors for proliferation in culture and generally more than one growth factor is required. Under usual culture conditions, growth factors are more rapidly depleted than other media components and thus become rate limiting for proliferation. The loss of or decreased requirement for specific growth factors is a common occurrence in neoplastically transformed cells and may lead to a growth advantage, a cardinal feature of cancer cells.

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a. Fast Delivery: 3 work days after received payment.
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c. Long Term Cooperation Discount: 5% DISCOUNT for our regular customers.

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Raw Powder
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18 Boldenone Acetate CAS :2363-59-9
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Blend 1 0.5mg cjc with dac + 0.5mg hexarelin + 1mg ipamorelin
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4. More Information About Live Cell Growth Factor:

The canonical model of receptor tyrosine kinase (RTK) activation assumes that ligand-induced dimerization of inactive receptor monomers is a prerequisite for autophosphorylation. For several RTK families, recent results of fluorescence microscopy provided evidence for preformed receptor dimers that may or may not require ligand binding for kinase activity. Here we report, for the first time, the application of advanced quantitative fluorescence microscopy techniques to study changes in the oligomerization state of the RTK Met in response to stimulation by its endogenous ligand hepatocyte growth factor (HGF). We used inducible C-terminal fusions between Met and enhanced green fluorescent protein (EGFP) or red fluorescent protein (RFP) in combination with fluorescence resonance energy transfer (FRET)-based fluorescence-lifetime imaging microscopy (FLIM) and fluorescence correlation spectroscopy (FCS). A small fraction of HGF-independent Met dimers appeared to be present in cells even at low receptor density. At high receptor density, both the fraction of Met dimers and the level of Met autophosphorylation increased in the absence of HGF. Stimulation with HGF at low receptor density significantly increased the fraction of Met dimers on live cells. We found no indications of Met oligomers larger than dimers. Our findings thus confirm a model of Met activation through HGF-induced dimerization and at the same time they support previous reports of Met dimers in unstimulated cells. The tools established in this work will be useful to further characterize the mechanism of Met activation and to define the contribution of co-receptors.

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

A certain piece of geographic knowledge in nature's lore (presented in the paragraph immediately below) perhaps best illustrates how peptide growth factors must be considered cell-to-cell signals, rather than as the equivalents of metallic parts of a machine. They offer up physiological symbols of communication within the organ systems of nearly all animal organisms. Peptides possess the unique action of serving as a significant means to convey information from one cell to another or from one organ to another, including the brain and central nervous system; their action in this regard is contextual.

Natural lore shows us the way peptide growth factors act to convey information inside their animal host. I ask you to visualize the reversal of host animal peptide growth factors communication in the following context:

It's a fact that in two closely located islands off the coast of South Africa, a rock lobster and a large snail have reversed their predator-prey relationships. On island "Gamma," the lobster preys on the snail: finds it, attacks it, and eats its soft parts with gusto. Fifty nautical miles to the east on island "Omega," a reversal of the roles between prey and predator takes place. The same species of snail that had been eaten, now preys on the same species of lobster by approaching it, extending a probing foot, burying that foot into the lobster's body, and sucking out its gizzards.

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6. Seller's Information:

Company: Shanghai Yijing Pharmaceutical Co., Ltd
Mob: +OO86-13O26163653

7. How to place an order:

Send me an email at the address above, tell me product name and quantity.

  CAS Registry Number:

00-00-0

  Company: Shanghai Yijing Pharmaceutical Co., Ltd     [ China ]        
  Contact: Alisa
  Tel: +86-130-26163653
  Fax:
  Email: alisa@pharm-china.com
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